5.5 years since diagnosis Chronic phase CML.
First 1 year on Gleevec 600 mg. Did not reach CCyR hence was asked to switch to TAsigna 800 mg.
switched to Tasigna 800 mg 4+ years (close to MMR). 0.1 (international scale)
Onc switched me to Sprycel 100 mg about 6 months back to push the response further and also due to side effects. There was some immediate drop in PCR.
First PCR on Sprycel - 0.05 (IS)
Second PCR on Sprycel (0.035) (IS)
Third PCR on Sprycel (0.040) IS
Any concerns between second and Third PCR. I was expecting it to incrementally go down this time but it marginally moved up. My onc considers this stable and ok to continue with 100 mg.
Any thoughts?? Should I worry.
Also I take lemon juice in hot water to manage my ALT/AST elevation 2 hours before or after sprycel.
Will it affect sprycel bio-availabilty?