. Hi everyone. I was dx last month on 3/26/2014 so I am new to all of this. I am wondering if a bone marrow biopsy/aspiration is necessary for CML diagnosis and treatment monitoring? My hem/onc is highly regarded in the medical community as a hematology expert but has done all my CML testing using the peripheral blood and not actual bone marrow as this is the usual course he takes with all of his CML patients. My hem/onc has stated that my PCR testing will all be done using the peripheral blood and he usually orders a biopsy if I stop responding to treatment or run into complications at some point. Should I be concerned?