I've seen a lot of information on the interaction between TKI drugs and PPI medications. I've been taking PPIs for many years due to GERD. Also, I was diagnosed with Barrett's Esophagus last year. This puts me at higher risk for developing esophageal cancer.
I was first on Protonix and now Dexilant. Since going on the Dexilant the GERD has been under control and the Barrett's has improved but I'm also having a slower than optimal response to my CML treatment.
I am currently on 100 mg Sprycel. At this point, I've reached CCyR, but my last PCR was still at 0.3% after about 17 months of treatment. I feel that the PPIs are likely contributing to this.
So what do I do? I have been trying to balance the amount of PPI in my system to increase TKI absorption but I feel like I'm stuck between the two extremes. Neither of which presents a good outcome. Is is worth it to lobby for another TKI change to Tasigna or should I just want to see if my trend gets me to MMR and stick with that?