I received my lab reports today and it was interesting to learn that 65% of my cells were Trisomy 8 (three copies of chromosome 8).
The Monosomy 7 which I had in my last bone marrow was gone (which is good news at least) - and bcr-abl FISH was not done since my PCR is borderline detection.
The Trisomy 8 is a puzzle and it is believed that Dasatinib (Sprycel) can cause it. Interestingly, the presence of Trisomy 8 may make Spyrcel more effective at treating the underlying CML hence why I may be responding so well to low dose Sprycel:
"Of particular interest is that the Lyn kinase gene is encoded on the long arm of chromosome 8," explained Komrokji. "The gene duplication may augment kinase response capacity and proliferation. What looks like preferential activity of dasatinib in patients with trisomy 8 could be due to the suppression of Lyn, a kinase that appears to aid in proliferation of the disease."
Regardless, I think I understand why I still have relatively low counts (anemia) despite having near complete remission... most of my cells are Trisomy 8. And why such a low dose of Sprycel seems to be effective for me (Curcumin notwithstanding).
I was told that the Trisomy 8 is not a concern, but bears watching (i.e. translate: more bone marrow tests are in my future!). I am bartering to stop Sprycel and test that Trisomy 8 goes away. We'll see if I can be my own trial on that.
Trey: if you would like to see the lab report PM me. I'd be happy to send it to you. M.D. Anderson is very complete in their descriptions of the slides, karotyping, etc. It was a fascinating read.