My previous bcr/abl was 0.005% on the International Scale, and my current one is 0.02% on the I.S. Can anyone tell me how to calculate the log increase? Thanks. Frank
Posted 28 March 2014 - 02:29 PM
What disease do you have? You might want to check in with that particular forum. Click the "Living with..." link and there is a list of illnesses and each is a link to a forum.
Posted 29 March 2014 - 05:20 AM
1 log (the way it is used to describe response) is one decimal place. The first result was 0.005 so for a 1 log increase you would need to increase to 0.05 i.e. the increase you have had is less than one log and based on the accuracy of the tests not statistically significant. Still loosing a 0 is never nice.
Dx Dec 2010 @37
2x IVF egg collection
Glivec 600 & 800mg
PCRU March 2012
Unsuccessful pregnancy attempt - relapsed, 3 months interferon (intron A), bad side effects from interferon
Nilotinib 600mg Oct 2012
PCRU April 2013, 2 years MR4.5 mostly PCRU with a few blips
April 2015 stopped again for pregnancy attempt (donor egg), pregnant first transfer, 0.110 at 10wks, 2.1 at 14wks, 4.2 at 16wks, started interferon, slow dose increase to 25MIU per wk, at full dose PCR< 1 for remainder of pregnancy
Healthy baby girl Jan 2016, breastfed one month
Nilotinib 600mg Feb 2016
MMR May 2016
PCRU Feb 2017
Posted 29 March 2014 - 12:39 PM
0.6 log. Divide one by the other and take the log of the answer. LOG10(A/B) in excel.
PCR tests are notoriously unreliable at those kind of levels and so it is within the limits of error.
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