I'm so sorry you are experiencing this so early in your treatment. I experienced severe liver toxicity 9 months into Gleevec treatment at 400mg. I noticed that my ALT after being very steady increased to 80. My local onc said he would watch it. Three weeks later I mentioned it to my Mayo oncologist when I saw him, he hadn't gotten my CBC/Metabolic panel back at the time of my appointment so he had them run another AST/ALT and do an ultrasound of my liver and those results both came back over 1,000, although the liver looked normal on the ultrasound. I immediately was taken off Gleevec to bring those counts back down and I was off for 7 weeks before they returned to normal. They increased to 1500 ALT/1300AST before dropping. We decided that it was unlikely I would be unable to resume Gleevec without the same results so I switched to Sprycel. I've never had a blip with those enzymes on Sprycel, although I did develop a pleural effusion and my dose was reduced to 50mg. and I've been on that for nearly 18 months with a return to MMR.
During the 7 weeks waiting for my counts to recover I did a lot of searching on the internet for liver toxicity and Gleevec. Though not common it occurs in 3-5% of those taking Gleevec. I came across an Italian study that treated patients with drug induced hepatitis from Gleevec with low dose corticosteroids (25-40mg per day). It was a very small study and I could never convince my docs to give it a try. I was very motivated because I was responding to Gleevec and had relatively few side effects.
I believe their premise for this study was that the liver toxicity was an inflammatory response to Gleevec and could be controlled with short low dose treatment with steroids. My oncs felt that the concern of liver failure and the option of two other drugs, at that time, was a better argument for switching.
I don't know what kind or how severe your side effects were on Gleevec, but because your drug treatment options have dwindled with the concerns over Iclusig and your 3-way translocation, is Gleevec something you would be willing to give another try?
The other thing is, I was told when switching from Gleevec to Sprycel that the same side effects are not necessarily experienced across the board, you may do fine with Bosulif. It is certainly worth the try!
I wish you lots of luck and hope to hear that things are going well for you in the very near future!