I was at 1.69% PCR in June then 5.63% in September so my doctor switched me from gleevec to sprycel. I was on gleevec 8 months and was over the joint/bone pain. Well now it is back and I hurt bad. Will the side effects start over? How long can this last? any suggestions? They said no Tylenol, ibuprofen,aleve, etc
Switched from gleevec to sprycel .. question
Started by
CML2012
, Sep 25 2013 06:50 PM
4 replies to this topic
#1
CML2012
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Posted 25 September 2013 - 06:50 PM
Diagnosed CML December 2012
Gleevec 400 mg
PCR 53%, 41%, 1.69%, 5.63% (Mutation test negative) September 2013
Sprycel 100 mg
PCR 1.1%, 0.2%, 0.2%, 0.6%, .09%, .06%, PCRU June 2015, PCRU Sept 2015, PCRU Dec 2015, 0.042% Mar 2016, 0.122% April 2016, 0.19% June 2016, 0.176% July 2016, .052% Sept 2016, .031% Nov 2016
Diagnosed Basel Skin Cancer December 2012, October 2014 (All cancer removed)
Diagnosed Melanoma April 2015 (All cancer removed)
Gleevec 400 mg
PCR 53%, 41%, 1.69%, 5.63% (Mutation test negative) September 2013
Sprycel 100 mg
PCR 1.1%, 0.2%, 0.2%, 0.6%, .09%, .06%, PCRU June 2015, PCRU Sept 2015, PCRU Dec 2015, 0.042% Mar 2016, 0.122% April 2016, 0.19% June 2016, 0.176% July 2016, .052% Sept 2016, .031% Nov 2016
Diagnosed Basel Skin Cancer December 2012, October 2014 (All cancer removed)
Diagnosed Melanoma April 2015 (All cancer removed)
#2
Trey
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Posted 25 September 2013 - 06:55 PM
To some degree changing TKI drugs means starting over with side effects. Not 100%, but close enough. It will take time to adjust.
Aleve should be OK unless there is another medical reason for you avoiding all NSAIDs.
#3
prljm10us
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Posted 25 September 2013 - 11:44 PM
has your doctor mentioned Tasigna it had far less side effects for me.
#4
paul_s
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Posted 29 September 2013 - 12:48 PM
In April/2012 my PCR had 'plateaued', so my Onc swithched me from Gleevec to Sprycel. Sprycel brought a whole new set of side effects.
Headaches for 3 weeks plus the joint,abdominal, lung stuff. Took 4 months and then side effects started to subside. Am now back to about
the point I was with Gleevec(w/o the muscle cramps). As always, YMMD (Your Mileage May Differ). BTW, Aleve works well for me.
"Hang in there" & POR (Press On Regardless)
#5
Ludwigh
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Posted 01 October 2013 - 12:10 AM
Cml2012. I am on Sprycel and have been for over three years. I use Ibuprofen and have never had a problem. I was told I could use it. Bone pain and nerve pain was quite severe for me and during the first two and a 1/2 years I had spells of extreme bone pain even after being PCRU for two years. Everywhere there is active marrow I had preasure, burning, tingling, needlelike pain; hips, spine, head, sternum, shoulder blades. So bad I had to take hydrocodone. Every time it happened I thought the CML was coming back and lasted about a month. Some it gets better, some it improves gradually.
I am doing ok and I lead a very active life now, however I do have spells.
Terry in Colorado
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