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Switched from gleevec to sprycel .. question

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#1 CML2012


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Posted 25 September 2013 - 06:50 PM

I was at 1.69% PCR in June then 5.63% in September so my doctor switched me from gleevec to sprycel. I was on gleevec 8 months and was over the joint/bone pain.  Well now it is back and I hurt bad. Will the side effects start over? How long can this last? any suggestions? They said no Tylenol, ibuprofen,aleve, etc

Diagnosed CML December 2012
Gleevec 400 mg
PCR 53%, 41%, 1.69%, 5.63% (Mutation test negative) September 2013
Sprycel 100 mg
PCR 1.1%, 0.2%, 0.2%, 0.6%, .09%, .06%, PCRU June 2015, PCRU Sept 2015, PCRU Dec 2015, 0.042% Mar 2016, 0.122% April 2016, 0.19% June 2016, 0.176% July 2016, .052% Sept 2016, .031% Nov 2016
Diagnosed Basel Skin Cancer December 2012, October 2014 (All cancer removed)
Diagnosed Melanoma April 2015 (All cancer removed)

#2 Trey


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Posted 25 September 2013 - 06:55 PM

To some degree changing TKI drugs means starting over with side effects.  Not 100%, but close enough.  It will take time to adjust.

Aleve should be OK unless there is another medical reason for you avoiding all NSAIDs.

#3 prljm10us


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Posted 25 September 2013 - 11:44 PM

has your doctor mentioned Tasigna it had far less side effects for me.

#4 paul_s


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Posted 29 September 2013 - 12:48 PM

   In April/2012 my PCR had 'plateaued', so my Onc swithched me from Gleevec to Sprycel.  Sprycel brought a whole new set of side effects.

Headaches for 3 weeks plus the joint,abdominal, lung stuff.  Took 4 months and then side effects started to subside. Am now back to about

the point I was with Gleevec(w/o the muscle cramps).  As always, YMMD (Your Mileage May Differ).   BTW, Aleve works well for me.

"Hang in there" & POR (Press On Regardless)

#5 Ludwigh


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Posted 01 October 2013 - 12:10 AM

Cml2012. I am on Sprycel and have been for over three years. I use Ibuprofen and have never had a problem. I was told I could use it. Bone pain and nerve pain was quite severe for me and during the first two and a 1/2 years I had spells of extreme bone pain even after being PCRU for two years.  Everywhere there is active marrow I had preasure, burning, tingling, needlelike pain; hips, spine, head, sternum, shoulder blades. So bad I had to take hydrocodone. Every time it happened I thought the CML was coming back and lasted about a month. Some it gets better, some it improves gradually.

I am doing ok and I lead a very active life now, however I do have spells.

Terry in Colorado

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