New Member
Posted 07 February 2013 - 07:08 PM
Hi
Hope everyone is doing ok.
I got my monthly blood results back and my ALT is 64.
My doctor said we should recheck it in a week. This is the first time to see my numbers out of normal ranges.
I'm very careful not to eat food with lots of fat in it, however the day before my blood was drawn I had some chineese food but not that much.
Should I be too concerend?
Thanks everybody!
Advanced Member
Posted 07 February 2013 - 08:27 PM
Hi Dina, My ALT hung out around that level most of the time I was on gleevec. Doc said it wasn't normal but wasn't a worry as long as it was pretty stable. I can't remember the actual point at which they actually start worrying but it is many times the upper normal level. It's good to get it rechecked to make sure that it is stable and not the start of much higher numbers.
Dx Dec 2010 @37
2x IVF egg collection
Glivec 600 & 800mg
PCRU March 2012
Unsuccessful pregnancy attempt - relapsed, 3 months interferon (intron A), bad side effects from interferon
Nilotinib 600mg Oct 2012
PCRU April 2013, 2 years MR4.5 mostly PCRU with a few blips
April 2015 stopped again for pregnancy attempt (donor egg), pregnant first transfer, 0.110 at 10wks, 2.1 at 14wks, 4.2 at 16wks, started interferon, slow dose increase to 25MIU per wk, at full dose PCR< 1 for remainder of pregnancy
Healthy baby girl Jan 2016, breastfed one month
Nilotinib 600mg Feb 2016
MMR May 2016
PCRU Feb 2017
Advanced Member
Posted 08 February 2013 - 10:07 AM
ALT is not only a liver indicator. It is usually a sign of muscle re-building after injury or stressful workout.
New Member
Posted 08 February 2013 - 10:35 AM
Thanks guys,
Well I do workout and did it two days prior my blood work was drawn,
I also did have some pain on my right lower ribcage, right under it but only when I touch it though...its all gone now.
Trey, do you think 64 is too high?
Dina
Advanced Member
Posted 08 February 2013 - 11:54 AM
Trey is correct.
Early in my Gleevec 400mg treatment, I got a CBC that came back with 160+ AST and 40+ ALT ... I absolutely freaked out. However, I had done a stressful gym/weights workout just a couple of days prior to bloodwork (and I had very sore muscles from the workout), so that's what caused it. The very next CBC saw my AST & ALT numbers return to normal ranges (20 & 16, respectively). And I found that once I moved into a steady workout routine, my AST/ALT numbers never spiked back up again ... as long as I stay in good shape and keep my regular workout routine intact.
Dan - Atlanta, GA
CML CP Diagnosed March 2011
Gleevec 400mg
Advanced Member
Posted 08 February 2013 - 02:52 PM
Dina,
My doctor told me that they don't get concerned about liver enzymes until they go over 100. That said, mine went from 80 to 1300 in two weeks 9 months after I started Gleevec, so, I would make sure they keep an eye on it until it comes back down. I haven't had any issues with elevated liver enzymes since I switched to Sprycel over 3 years ago.
Good luck!
Pat
Pat
"You can't change the direction of the wind but you can adjust your sails."
DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>
Advanced Member
Posted 08 February 2013 - 04:55 PM
It sounds like you had a slight muscle pull. Even such a slight pulled muscle can send the ALT much higher for about 3 days. I would expect that the ALT would be more normal next time if it has been consistently normal all along. ALT is an indicator of tissue "damage" (also hard workout stress, which is a form of damage and repair), and is more often related to muscles than the liver.
0 members, 1 guests, 0 anonymous users
