I know it's been a while, I have a few questions about Ponatinib. I'm starting with 45mg tablets of Ponatinib SID tomorrow and i'm nervous about what to expect. I originally was on Tasigna 300mg for 6 months and it stopped working, then Gleevec 400mg for 6 months and it stopped working so they upped me to 600mg of the Gleevec but the i was throwing up so much that I wasn't getting a theraputic enough dose to even see if the higher dose would work, not to mention all of the other lovely side effects. My oncs did the mutation testing and luckily there were no mutations detected. Their theory on why the Tasigna and Gleevec treatments stopped working has to do with a genetic disorder called "Incontienta pigmenti" that I have as well. The theory is that the drug works initially and some where down the line (Usually after 3 months) the two genetic issues cross paths (the IP and the Ph+ CML) where the treatment is stimulating the IP to increase cellular production which is cancelling out the effectiveness of the treatment and then causing it to eventually be ineffective. It's a theory, there is no information or evidence to back up this theory, because, well, there is no infomation about IP and CML together. Anyhoo i'm pretty stressed out about trying the Ponatinib, maybe because I've had such a hard time with the TKI's. My onc is exhausting every option before there's any thought about doing a BMT. Anyhoo I'm just looking for some reassurance and what to expect from some others who have been where I am with failed TKI treatment and now being on Ponatinib.