9 replies to this topic

[TeddyB]

http://www.thestreet...oo&cm_ven=YAHOO

Wow, that was faster than expected

[PhilB]

Iclusig??!  How on earth did they come up with that?  Did they fall asleep on the keyboard?

However stupid the name, it's still well worth celebrating.  Preferably with a glass of ponatinib blanc.

Phil

[TeddyB]

Im having a glass of good Chianti.

Cheers PhilB

[CallMeLucky]

Try telling another doctor you're taking Gleevec and a couple look at you with this face that says "I've heard of that, remind me what it does"

Tell a doctor you are taking Sprycel and the response is "so how do you spell that?"

Now try telling a doctor "I take Iclusig" and see what the response is.

[WoofWoof]

Yes but at what risk: From the Ariad website "Cardiovascular, cerebrovascular, and peripheral vascular thrombosis,      including fatal myocardial infarction and stroke, have been observed.      Serious arterial thrombosis occurred in 8% of Iclusig-treated patients.      Patients with cardiovascular risk factors may be at increased risk for      arterial thrombosis with Iclusig. Interrupt and consider dose      modification or discontinuation of Iclusig in patients who develop      arterial thrombotic events."

The website for Iclusig http://iclusig.com/

[Trey]

Two "black box" warnings about dangers of liver toxicity and arterial thrombosis (blood clotting).  That may limit Oncs prescribing it for only T315i mutation patients.  But good to have an approved T315i drug.

[acb]

Do the other TKIs have black box warnings? Just curious ...

[Trey]

Only Tasigna, for elongated heart QT cycle.

http://community.lls.org/message/36646

[Thomas177]

Sudden deaths have been reported in patients receiving nilotinib (Tasigna) http://www.pharma.us...pdf/tasigna.pdf

[Trey]

That was  during clinical trials as far as anyone knows.  Also thought to be patients with prior cardio problems.  I have not heard of any QT cardio deaths since FDA approval.