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Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond


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#1 cousineg

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Posted 25 November 2012 - 09:58 PM

See this article Novel Agents In CML Therapy: Tyrosine Kinase Inhibitors and Beyond

See also these links:

                                   Bosutinib

                                         Bafetinib

                                             Danusertib

                                                     Ponatinib

                                                           Rebastinib

                                                                    Omacetaxine

                                                                              Radotinib



#2 alexamay09

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Posted 27 November 2012 - 06:32 AM

Great article, thanks.

alex



#3 Tedsey

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Posted 29 November 2012 - 04:24 AM

Thank you.  This is a very hopeful article.  May we all live long enough in the chronic stage to benefit from some of these suggested therapies.  May these advances happen in what is reasonably soon for us (i.e. not like a breakthrough in 10-20 years, which in the research world is considered quick).  Presently, our only hope for survival, if our disease progresses today, is a successful SCT.  And if successful, a hope that GVH or other complications therefrom does not snuff us out faster than what the CML would have. 

Long life, or, at least, an average lifespan to all of us,

Tedsey



#4 Trey

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Posted 29 November 2012 - 09:36 AM

Tedsey's new slogan:

"LIVE AVERAGE!"

We should make T-shirts.



#5 PhilB

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Posted 29 November 2012 - 10:51 AM

Trey wrote:

"LIVE AVERAGE!"

We should make T-shirts.

Only if we can have a picture of Don Bradman on the front - test batting average 99.94.  Come on guys, lets show some ambition here!



#6 CallMeLucky

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Posted 29 November 2012 - 12:30 PM

http://en.wikipedia....Life_expectancy


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#7 TeddyB

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Posted 29 November 2012 - 02:33 PM

Live long and prosper. (For those who get it)



#8 PhilB

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Posted 29 November 2012 - 03:10 PM

What about those who aren't getting it?

http://www.youtube.c...h?v=GysVngf7GrE



#9 Trey

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Posted 29 November 2012 - 11:01 PM

A duck and a Brit walk into a bar.  The Brit should have ducked.  Speaking of ducks, the record for the most ducks in Test cricket is 43.  Speaking of which, those who don't "get it" as Phil suggests may also be declared to be "out for naught". 

So maybe our T-Shirt says "LIVE AVERAGE AND DO O.K." on the front and on the back it  says "Stay Back 30 Feet -- TKI at Work".  






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