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Disolving Gleevec in water.


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#1 TeddyB

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Posted 24 July 2012 - 07:51 AM

Would there be any risks involved dissolving Gleevec in water? (I know Trey will have some comments about this as he has had some in the past )

What is the difference between swallowing the pill and dissolving it in terms of Gleevec efficiency?

Novartis states in the Gleevec "manual" that it is okay to dissolve it, im just curious what the downsides(or upsides) would be, if any.

Ive been dissolving G in water for 3 months already, and so far no issues. CHR between 3-4 weeks

As ive not found a single person doing this other than myself, im feeling like somewhat of a guinea pig

If anyone else also does this, please share.



#2 Rissa

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Posted 24 July 2012 - 09:03 AM

I don't see any reason why it would be less efficient.  We're supposed to take the pill with a large glass of water anyway.  Whether you dissolve it or not, I don't think it matters. 



#3 Trey

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Posted 24 July 2012 - 12:19 PM

Novartis lists dissolving in water or apple juice  as an acceptable method of taking Gleevec.  Many other fluids are fine I'm sure.  Infants take it this way.

http://www.webmd.com...me=gleevec oral

Efficiency is unaffected.  It also shows that it does not increase sharts since you don't have them.  So much for the "don't split the pills cause the open end causes sharts" myth. 

I'd puke my guts out.  But since you grew up eating Lutefisk, you would probably not puke on anything. 



#4 TeddyB

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Posted 24 July 2012 - 12:53 PM

Rissa: Thanks for replying, thats what i would think aswell

Trey:

The statement about puking is fairly correct, but i do puke from large amounts of Brennevin or Akvavit

Its gonna be awhile until i can drink in large amounts again, and its not something i strive for as its not very good for one`s health.

Good to know about efficiency not being affected, and you are right about the sharts, i haven`t had them since i started on Gleevec, i have however been having issues with constipation, but its usually managed with added fiber to my diet.

I have gotten the 100mg pills now, and i will probably start swallowing them soon.

On a small side note, 1x400mg pill tastes a bit different than 4x100mg pills, not worse or better, just different. Maybe its the coating.



#5 CallMeLucky

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Posted 24 July 2012 - 12:58 PM

Perhaps you can look into this and avoid the whole process

http://www.prnewswir...-137170103.html


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#6 Rissa

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Posted 24 July 2012 - 02:11 PM

I wonder if they'll have assorted flavors.  Cancer killing "life savers"?  I'm in!  



#7 TeddyB

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Posted 24 July 2012 - 02:37 PM

Im in on that aswell Rissa!

Indeed that sounds promising CallmeLucky, and if was offered something like that i probably wouldn't say no

Ive also thought about what if i have to go on Tasigna, but i saw that could be taken in applesauce, yummi.

Sprycel comes in 20, 50, 70 and 100mg, so one of those should be easy to swallow.



#8 Trey

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Posted 24 July 2012 - 03:15 PM

That "subligual Gleevec" thing is a hoax.



#9 CallMeLucky

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Posted 24 July 2012 - 04:11 PM

Really?  I didn't know that.  How did you find out it was a hoax?  And why would someone make something like that up in the first place?  I don't get it.  I mean if it was Nigerian prince that wanted to give me Gleevec I might have been a bit more suspicious.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#10 TeddyB

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Posted 25 July 2012 - 03:15 AM

Got my first pill down my throat without dissolving, took it in two halves, yay!

I think it might actually be easier to take the whole pill, cause it does not have the sharp edges you get when splitting.



#11 Trey

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Posted 25 July 2012 - 09:52 AM

http://community.lls.../message/129278



#12 Trey

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Posted 25 July 2012 - 09:54 AM

When I used to split the 400mg pills I would chew up some food and then swallow the half pill with the wad of food, and it went down more easily. 



#13 TeddyB

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Posted 25 July 2012 - 09:56 AM

Good advice, thanks.






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