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Gleevec through the mail?


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#1 lifeismusic

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Posted 10 July 2012 - 11:02 AM

I switched insurance carriers and gleevec will now be mailed to me.  My concern is that we live in a pretty extreme climate where temps can range from 100 degrees in the summer to -20 in the winter (Western Wisconsin).  I call Novartis and they did not have an answer as to whether or not this would be safe.  Does anyone have a similar situation or thoughts on mail delivery?

Thanks,

Chris from the Northland



#2 Rissa

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Posted 10 July 2012 - 11:31 AM

I used to have my gleevec delivered via FedEx and I always had someone there to sign for it and take it in the house.  Now I pick it up at CVS.  I don't know if extreme temp changes have an effect on gleevec, but it probably does.  I know gleevec can be dissolved in water for people who don't like taking pills.........  On the other hand, I have left my pills in the car in 100 degree heat for an hour or so and they were fine.  I'm not helping, am I? 



#3 CallMeLucky

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Posted 10 July 2012 - 11:52 AM

The pills are sent to the pharmacy via the same parcel carriers that would deliver to your home, so they are exposed to climate in the normal course of transit.  You should be able to insist on signature required if you are concerned about it being left in your mailbox on a hot day.  During the warmer months I have received it in a box packed with ice packs.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#4 LivingWellWithCML

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Posted 10 July 2012 - 02:39 PM

Same here.  Mine gets shipped via UPS overnight and they include cold packs in the box ... although I usually remind Curascript to make sure it's packed appropriately.


Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg


#5 0vercast

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Posted 10 July 2012 - 03:10 PM

I was a little concerned about that too, but the pills never sit out on the step in the sun since a signature is required upon delivery.  Remember, if you don't require a signature and your pills get ripped off, you can bet that your insurance company will not pay for replacements.



#6 Marnie

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Posted 10 July 2012 - 07:51 PM

I used to get mail order and it worked great.  I required a signature on deliver . . .Overcast is right. . no signature and you are stuck with replacement cost. . .not worth it.  I used Curascript and they had multiple addresses for me on file.  During the schoolyear it was delivered at school (I'm a teacher) and the secretary signed for it.  Summertime, it was delivered at home and I signed for it.  They could give a delivery time and day down to the hour.  Very convenient.

No way I would use mail order and not require a signature.  One person on this forum told about a time hers didn't get delivered and the insurance company was going to make her pay for replacement, but they had no record of it being delivered to her (no signature, even though she required it) and she won her case. . replaced by the insurance company.  Somehow, it had gotten stolen off of the truck. 

Marnie



#7 LivingWellWithCML

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Posted 10 July 2012 - 09:12 PM

Given the cost of TKI and the fact that some of us order 90 day supplies, I wonder if we could require a fingerprint or retina scan? :).  Seriously, great point on requiring signature ... Definitely the right way to have this stuff shipped to us!


Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg


#8 Susan61

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Posted 10 July 2012 - 09:22 PM

Hi:  There is no problem, and as a matter of fact I just got my shipment today.  It was packed in Ice which is what they do in the warm temperatures. I do not worry about the cold temps in the winter.  IT is delivered to me overnight, and I do sign for my pills also.  They advise you that if you do not sign,and they get lost you are responsible for replacement cost.  I always schedule my pills at least a week or more before I run out, and I also make sure I keep the day free to sign for them.  It works out fine, as long as you follow that system for delivery.  My pills come UPS.

Susan



#9 Guest_billronm_*

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Posted 10 July 2012 - 10:12 PM

Hi,

  When I was on Gleevac it was delivered to me in a small styrofoam cooler with 2 cold packs in it. It came by fed-ex, or ups. I always sign for my meds. I'm on Sprycel now and it is delivered by ups in a large envelope. So Gleevac must be more temperature sensitive than Sprycel. Those little coolers come in handy. They hold 4 beers!            Billie



#10 lifeismusic

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Posted 10 July 2012 - 10:25 PM

Thanks, Susan and thanks to all of you who replied.  I did call Novartis about this issue and they are supposed to respond within 24 hours (haha).  I believe that the signature requirement is the best route, but I'm still going to push for local Walgreen's delivery.  It's not that I don't trust the fedex corporation as I'm sure they are always placing the patient  first (read between the lines), but I'm still a little perplexed about how an ice pack will keep the medication at the right temp range on a 105 degree day.  That ice pack would work for about 12 minutes.  Anyway, it is comforting to know that the mail is working for many of you. 



#11 CallMeLucky

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Posted 11 July 2012 - 06:21 AM

It should be dry ice, which will last quite a bit longer


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#12 pammartin

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Posted 11 July 2012 - 08:15 AM

Sorry for the hijack, Billie, you have two private messages........not sure if you are checking them lately.  thanks Pam



#13 Susan61

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Posted 11 July 2012 - 04:39 PM

HI:  It comes in a styrofoam cooler. Very small, but even reusable.  The bottles are packed inside with the 2 packs of dryice, and its Ice Cold when  I open it.  You have to remember too that it is sent overnight.  Its not sitting on a truck in transit for days.  I cannot use a local pharmacy for my Gleevec like Walgreens or CVS etc.  When we have used a local pharmacy we got a letter telling us we could only use them twice, as they contract with your insurance company.  Now this was not for my Gleevec.  I am talking about at times when my husband would be put on a new medication for only 30 days to be sure it would work before we had to go mailorder with a 90 day supply.  I do not think you mentioned if you have to order so many like doing a 90 day supply like I do.  As you can see we all have had good results using the mailorder sytem.

Susan



#14 idahobeavers

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Posted 15 July 2012 - 09:26 PM

i get my sprycel thru walmart specialty pharmacy. it comes in a cooler inside a box and it has reusable ice packs in the cooler. isomeone has to be here to sign for my meds. so sprycel must not tolerate the heat. mine come from florida i live in oregon and i get it the next day



#15 hannibellemo

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Posted 16 July 2012 - 05:54 AM

I live in the same temperature zone as you and I have never had any of my meds (Gleevec or Sprycel) delivered in a cooler from any of the several specialty pharmacies I have used over the past 3 1/2 years. I suppose if we need to worry about the heat we should think about frigid temperatures as well. I wonder if all the drugs delivered to pharmacies come in coolers? They get overnight delivery, too.

I don' t worry about it at all since I get them overnight and the exposure at either extreme is a very short period of time.

Pat


Pat

 

"You can't change the direction of the wind but you can adjust your sails."

DX 12/08; Gleevec 400mg; liver toxicity; Sprycel 100mg.; CCyR 4/10; MMR 8/10; Pleural Effusion 2/12; Sprycel 50mg. Maintaining MMR; 2/15 PCRU; 8/16 drifting in and out of undetected like a wave meeting the shore. Retired 12/23/2016! 18 months of PCRU, most recent at Mayo on 7/25/17 was negative at their new sensitivity reporting of 0.003.<p>


#16 LLsurfer5@gmail.com

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Posted 16 July 2012 - 06:52 AM

Hi Chris:

I live in Florida- pretty extreme temps as well. Last shipment I got from UPS was packed in cooler with frozen gel packs. They are pretty good about that no matter what carrier your company is using. Don't worry about it, the most important is after you get them not to keep them in direct sunlight or warm moist area's.  A bathroom is NOT a good place for this medicine with all the humidity. I keep mine in the kitchen with the rice and pasta - at least I know that is a dry cabinate and gets good air circulation.

Hope you have a great day

Don't sweat the small stuff/

Laurie



#17 CallMeLucky

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Posted 18 July 2012 - 10:43 AM

This post wound up being rather timely.  Just got my Rx in the mail yesterday and it was laying on my porch in the sun in a plastic bag.  Temps were well over 90's the entire day.  I was recently switched to a new mail order pharmacy and I was concerned something like this would happen.  Last month they sent without an Ice pack and I was concerned but it wasn't as hot and I figured it would be alright.  This time I was not willing to let it go, especially since I told them when I ordered it to make sure it was put on ice.

I called the pharmacy, after 10 minutes or so wrestling with automated system I got someone, they transfered me to a pharmasist who "accidently" hung up on me.  I called back and after 10 minute automation hell was put on hold and left there for over 20 minutes.  I finally hung up and called back.  Started getting angry with them, asked to speak to a manager and explained this was no way to treat a "sick person" (I figured I might as well play the card since I was getting zero courtesy anyway).  I told them it was obvious someone screwed up and no one wanted to deal with it, but I wasn't going away so they might as well just deal with me.  I finally got a rep who said they didn't think it was a problem but I should talk to the pharmacist, I agreed that was a good idea given I was unsure of the qualifications of the person answering the phone and their ability to assess what kind of effect high temperatures could have on Gleevec.  The pharmacist came on the phone and read me the information from Novartis, which I also happen to have open in front of me.  It states to store at 77F with "excursions" permitted up to 86F.  He then told me yesterday was in the 90's, but he felt it probably wouldn't be an issue.  I said "the guidelines state nothing above 86F and we agree it ws well over 90F so why don't you think it is an issue?"  He then said "if you want me to send another one out, I will do it".  I responded "since my life depends on this drug working properly, why don't we err on the side of caution and resend it, this time packed in ice".  He agreed and they are shipping out another bottle tomorrow.  He told me next time I should request it be packed in ice.  I told him I did request it this time and regardless it was his responsibility to make sure it was packed properly.

The sad thing is, I have no doubt that they will get it back and put it back on the shelf.......SIGH!!!!


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#18 Happycat

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Posted 18 July 2012 - 09:22 PM

Personally, I'm a bit jaded about the temp thing. Just looking at the structure, I don't see anything that would happen at temps ca. 100 deg F. Heck, I heat compounds like that in the lab to 50 deg C all the time, so that's about what - 130 deg F? 

I know, I know, they put a temp excursion in their product literature, but I think that's more likely legal CYA, not a known temp stability problem. If I had time, I'd go look up stability studies on imatinib, but I've gotta get up at 4 am, so that not going to happen.

Anyway, you guys do what makes you feel comfortable. I'm personally not going to worry if my gleevec sits outside at 90 deg for an hour or two. If it sat outside at that temp for a week, yeah, maybe I'd be concerned then, but a brief temp excursion isn't going to worry me, not for this compound anyway.

My two cents,

Traci



#19 CallMeLucky

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Posted 19 July 2012 - 09:51 AM

Thanks Traci - I appreciate your thoughts on the subject given your line of work.  What are your thoughts on the downside temperature?  At what point would consider it to be too cold?  I had to laugh when I got the new shipment in the mail today it was packed in a giant foam cooler with 6 ice packs in it.  I immediately thought to myself, "Gee were they packed too cold?"  Does the worry never end?


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#20 0vercast

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Posted 19 July 2012 - 09:03 PM

I'm a little disappointed that my Gleevec didn't come with any cold packs or protection from the heat when I received a shipment on Tuesday.  They came from upper-90's Pennsylvania to low-90's Minnesota via overnight UPS, and the box was pretty warm upon arrival.  At $201 a pill, I expect a little more thoughtfulness, to be honest.  I hope they're still potent.






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