2 replies to this topic

[eithne01]

Hi everyone, Has anybody here on a TKI being diagnosed with hardening of the leg arteries after being on treatment for two years? symptoms starting

shortly after beginning treatment?

[TeddyB]

Which TKI are you on? Sprycel?

It can cause pulmonary arterial hypertension, but i have never heard of hardening of the leg arteries due to a tki, even though i am fairly new to CML. Im sure some of the other board residents can help you out.

[Trey]

Peripheral arterial occlusive disease (PAOD) has been associated with Tasigna in some rare cases where other diseases (such as diabetes, etc) were also present. 

http://emedicine.med...460178-clinical

http://www.haematolo...96/10/1395.full