I have nt posted in a while, I guess had become quite relaxed after my mother's last PCR test in Jan'12 which was 0.6%. However we did her test again last week and the report came in today. I was shocked to see her pcr at 13.39 %. I will be taking the doctor 's appointment for tomorrow but till then i was hoping to get some answers here.
She was diagnosed with cml in sep 2010 with the following dosage and PCR results :
Diagnosed in Sep'10, Gleevac started on 28th Sep '10
PCR in Jan '11 - 17% (400mg Gleevac)
PCR in May'11 - 12.35% (dosage increased to 500 mg)
PCR in Oct'11 - 12.5 % (dosage increased to 600 mg)
PCR in Dec'11 - 0.3% (dosage on 600mg)
PCR in Jan'12 - 0.6%
PCR in May'12 - 13.36% (Between the months of Jan '12 and May'12 , she has been slightly irregular with her dose due to nausea and flu in India; nevertheless she has taken 400 mg most days and would have missed the dose completely may be twice or thrice)
I am worried that does that she has developed resistance to the disease in these couple of months or she needs to be regular on 600 mg to control the disease.
From everything that I have read , once a patient reached under 1 % PCR then the chances of disease progression or resitance are very low. Is that so ?
Are there any people in this forum whose PCR would have shot up so drastically and then came back down..
I am very disappointed with my doctor her in India, after her 0.6 % pcr he asked her to reduce her dosage to 500 mg . i was nt completely conviced with this so I had posted in this forum in Jan and another group that I am part of . And they all said to continue on 600 mg so she as been taking 600 mg on and off
Trey, I am hoping you ll be able to help me her with the next few steps.
Hoping for some answers before doctor's visit tomorrow.