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Changing dosing schedule

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#1 Taylor



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Posted 02 May 2012 - 07:34 PM

Hi all,

I'm thinking about changing my dosing schedule with Tasigna (150mg x 2 bid).  I have been doing 10:30AM in the morning and 9:30-10PM at night.  I want to do something like 6AM and 5PM.  With work and just my schedule now that I'm married, I end up getting up around 6AM anyway but I don't eat until after 7.  Also the 5PM will help a lot with eating and drinking later for social reasons.

I am wondering if I need to do anything special fror making a change like this.  I know Tasigna can be, if necessary, dosed on a 16/8 hour interval, but I'm kind of worried about doing a 12 hour interval after the 8 hour after making this switch (i.e., taking it at 10AM, then 6PM, then again at 6PM).  It would probably just work out of my system in a day, but I wanted to be sure I shouldn't try to skip a dose and "reset" or anything like that.  Thanks,


#2 Lori's okay

Lori's okay


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Posted 02 May 2012 - 09:39 PM

HI Taylor,

Not completely sure I understand your concern.

But, if you take it at 9:30 or 10 at night then at 6am the next morning that would be 8 1/2 to 8 hours.  That should not be a problem.  My only worry would be if you needed to take it less than 8 hours apart.  I'd worry more about going a little too high on the blood levels than too low.  Anyway you cut it, we all miss a dose now and then and the world does not end.  I try to nearly never miss, and think that's important.  But, my onc is much more comfortable with a miss now and then. 

(I am on 450mg a day, taken one in am and two in pm....so obviously my blood levels vary, I'm early in treatment but responding really well.)

Good luck.


DX 09-2011 PCR 8.08 not IS WBC 17 , Began Tasigna 600mg  

in 2012 Tasigna 450mg/day ,in 2013-2017 Tasigna 300mg/day


09-11/ 8.08 not IS

03-12/ 0.054 not IS

06-12/ 0.035 not IS

09-12/ PCRU, 01-13/ PCRU

4-13/ 0.042 IS

7-13/ 0.014 IS

11-13/ PCRU, 04-14/ PCRU

8-14/ 0.006 IS

PCRU: 12-14/ 05-15/ 10-15/ 02-16/ 

09-16/ 02-17/ 09-17/ 

10-17 tapered off 

11-3-17 Stopped Tasigna

1-15-18 still PCRU


#3 Guest_billronm_*

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Posted 02 May 2012 - 10:26 PM

Hi Taylor,

  I doubt  if a few hours difference would matter one way or another, as long as you get both doses in you. I have forgotten to take my Sprycel a few times and my bw is fine. I could never follow the schedule for Tasigma.                     Take Care Billie

#4 Melanie


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Posted 03 May 2012 - 04:58 PM

Hi Taylor,

I take my doses at about 6:00 am and 4:30-5:00 pm. Works fine. Sometimes due to afternoon activities, (eating late lunches, snacking with the grandchildren, etc) I don't get the 5 pm one on time and have to move it to later after dinner. End up delaying it to 9 - 10 pm. I haven't noticed any big difference.  Hope that helps.

Blessings, Melanie

Dx - 05/2011; PCR: 15.04; Fish: 87% Slow responder due to pancytopenia. Current - Bosulif - Nov: 2012, Mar 2016 lowered to 300 mg. 07/16 back to 400 mg. Clinical trial drug, Promacta, Feb 2013, for low Platelets.
CyCR - Aug 2014, Positive for 1 chromosome Sep 2015. PCR: 12.77 in Oct, 2012 to 0.04 (MDA) in Mar, 2016. 4/2016 - 0.126 (Local lab (IS); 05/2016 - 0.195 (local); 6/2016 - 0.07 (MDA); 7/2016 - 0.03 (local) 9/13/2016 - 0.16 (MDA); 9/26/2016 - 0.31 (MDA); 11/2016 - 0.012 (local); 01/2017 - 0.24 (MDA); 04/2017 - 0.09 (MDA); Cytogenetics show der(1:7)(q10;p10)7 chromosome mutation. Repeat of Sep 2015. PCR - 6/2017- 0.035 (local); 10/2017- 0.02 (MDA)

#5 sarabrooks83


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Posted 03 May 2012 - 06:10 PM

I think once you make the switch and commit to it, you'll be fine! The body responds very well to routine, so just make sure that the first week on your new schedule is solidly in place. Maybe try setting an alarm on your phone in order to remind yourself during the initial switch over period!

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