Hello all. Directing this 1st to Trey then to whoever else might have some insight.
I'm 2-1/2 years into CML, t315i for 1 year, on trial drug Ponatinib for 10 months with some success although the sides are difficult.
I have been resisting a BMT since I'm a single parent of a high school junior, trying to hold on till he is out of high school in 2013. My best friend recently discovered that an employee of his has a wife who is a Dr. @ a leading NCI hospital. As a favor he asked the woman some specific questions about my situation and my expected outcome if I go the BMT route. The answers were frightening & unexpected although I guess the stats were available to me had I bothered to do the research.
In summary; I'm in chronic phase now with t315i. If I wait till & if I ever progress to blast phase for a transplant the success rates are 80% at 3 months, 10 % at 12 months. There also some issues with time between dx & BMT decreasing the chances for survival.These are not encouraging numbers for survival.
So of course my friend is of the mind that I should immediately begin plans for a BMT. The debate is; how long can I maintain on the trial drug and avoid the BMT. Also does the t315i change my chances for success with the BMT, also before blast phase there is the accelerated phase- what are the differences between these two phases?
So, what would you do? Maintain the trial & hope for the best, move toward the BMT asap to get the best possible chance at survival?
Thanks to all and best of luck with the battle.