Hi Pin,
There is a recent paper, Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells, Min Tang, Mithat Gonen, Alfonso Quintas-Cardama, Jorge Cortes, Hagop Kantarjian, Chani Field, Timothy P. Hughes, Susan Branford, and Franziska Michor, BLOOD, 11 AUGUST 2011, VOLUME 118, NUMBER 6 :
http://bloodjournal....118/6/1622.full
It's possible that you can only see the abstract - I am posting from within a university so I can read the whole paper. The first part of the paper involves statistics where they plot the average PCR results for a reasonably big group for the first year on a log plot and fit straight lines to various parts of the data i.e. the first 4.5 months can be modeled by very steep straight line (i.e logarithmic response) and from 4.5-12 months a much less steep straight line. Then they do the same thing for long term (10 years) response. Then as Trey has done they go on to reason why you get these phases of response. You and I are still most interested in the first year, although my first year finishes tomorrow, also my birthday :-). The average first year on glivec looks like this:
If you plot my data it has exactly this shape but the first straight line is a bit steeper than average.
I don't know if posting that violates anything... guess we'll see. If I disappear and you never hear from me again ya'll know what happened.
The long term response curve has the same shape and that is the one they are discussing in the abstract:
Anyway the result of all my campaigning to change to a 2nd generation drug is on hold until the 7th of next month when I get to see the specialist doc. My doc is happy for me to stay on 800 glivec until then....sigh. She'll do another PCR in the mean time.
