I much appreciate your reply to my post. I realize that precautions, dose levels, and side effects are based on those patients that braved the clinical trials. But, the 2 hours, 1 hour and 12 hours between doses are arbitrary, easy to remember numbers. The people that responded before you had a chance to ask their ONC's and some of the keys ONC's in the fight against CML, what times are important and which ones can be fudged.
I remember being so scared before starting Gleevec. The nurse that gave me my teach session kept stressing to take it with food. I asked how much. Did I have to go to an all-you-can-eat buffet or would a couple cookies or 8 oz. yogurt in the morning be enough. Of course, she didn't know and I'm sure my individual digestive system was important. In five years, I found that the cookies or yogurt were enough for me. On two or three occasions where I took Gleevec before going out to eat, rather than taking the pill in a restaurant, I actually threw up the pill within about 20 minutes. My stomach knew something wasn't right.
In nine days on Tasigna, I still feel great. I have found taking the first dose upon waking the easiest and then waiting one hour to eat. I take my second dose about 10 hours later, before leaving work, easily two hours after lunch. By the time I get home, look at the mail and hear my voice mails, I can eat.
Again, much appreciate your reply and all the others before you.