Anyone have Monosomy 7 and/or Trisomy 8 in their BMB reports? (even with Ph+ = zero)
Cytogenetics: Bone Marrow
Started by
scuba
, Dec 08 2011 11:15 AM
4 replies to this topic
#1
scuba
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Posted 08 December 2011 - 11:15 AM
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
#2
Pin
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Posted 08 December 2011 - 05:27 PM
Hey, I remember a member recently saying they had Trisomy 8, I searched the forum - it's under a thread called "lost!!!".
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14
#3
Happycat
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Posted 09 December 2011 - 04:40 AM
Didn't Hans have trisomy 8 show up in a few of his reports? I remember he had something like that show up.
Traci
#4
HPL
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Posted 09 December 2011 - 02:21 PM
Hi, this is Hans.
I have had Monosomy 7 show up in my reports, anywhere from 2/20 to 4/20, and on Fish it was as high as 14%, but recently it's around 1 to 2%. The deletion is internal, ie. not a complete deletion of 7. I also had some Monosomy 11 come and go,hasn't been on my last 2 cyto reports, but on Fish it's around 1%. I had one Cyto report come back with 1/20 as Trisomy 8, but it wasnt present in Fish, and as Dr. M states, it could very well be due to the instability of the test. Labs typically don't report a singleton in terms of evidence of a clonal abnormality. Haven't seen it since.
All of these were in my PH- cells. I am currently PCRU (waiting on my last test), and my blood counts are generally pretty good. But I do know that Monosomy 7 can pose some risks, but then again,it's transient more often than not. Just something to keep an eye on as my doctor would say. The only reason I even know about these are that I'm still in the Ponatinib trial, and get a BMB every 6 months (used to be 3 months), otherwise I wouldn't even have to have a BMB. I wonder how many of us who don't get regular BMB's anymore have transient abnormalities, but we just don't know.
Best wishes,
Hans
#5
scuba
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Posted 09 December 2011 - 03:22 PM
Hi Hans - Thanks very much - this is exactly what I was searching for.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"
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