I've been on Gleevec 300mg since I was diagnosed in May 2007. I saw my onc a few days ago. Every time I go in, I complain about fatigue. We've discussed switching drugs before, but always stuck with 'the benefits outweight the side effect of fatigue' arguement. I'm just so frustrated with being so tired all the time. I work full time and I use all my energy for work. Fatigue has been a quality of life issue. The fatigue was much worse at first but improved around 6 months after starting G and again after about a year.
This time she said she is comfortable switching me to either Sprycel or Tasigna. She left it up to me. I have had an excellent molecular response to Gleevec. My Quantative PCR's have been negative since Dec 2008. (My first onc never performed a PCR, so I could have been PCRU prior to Dec 2008, however I acheived CHR and CCR within 6 months of taking G).
Has anyone else switched from G due to a non-hematological side effect? I know that everyone's response to the meds are different. I am worried that I am trading in one side effect (fatigue) for something worse. I am leaning towards Sprycel. I believe she said that is a once a day and doesn't have the food restrictions that Tasigna has. Also, I am worried about the QT black box warning with Tasigna.
Thanks for any advice or comments