I have come into contact with a small number of parents whose children have CML. Most comment that their children's height has been affected since CML treatment. Obviously response to TKI's is the most important thing but I think many of us are wondering what extent the growth impairment will be, is their height the only thing affected or would this have other implications and is there anything we can do?
My own Son's age/height ratio was in the Aus/NZ 95percentile when he was 2 years old. At nearly 6 years old (we had his 3 year CML anniversary in September) he is now lower than the 1 percentile.
Kayne is on Dasatinib and I found this article but so much of it is beyond my understanding and I'm not sure which articles to give the most attention to.
Another mum posted yesterday (in a different section of this site) questioning the growth issue for her son on Imatinib. Here is one poster article for CML children on Imatinib http://www.posterses...P_670_16eha.pdf
When the kids reach a stable response, would platelet derived growth factors (or alternatives) be something we should look at? If so, are there known side effects?
Would appreciate anyones thoughts or further knowledge in this area.