Posted 01 October 2011 - 05:32 PM
A few years ago, after I was dx'd, and after about six months on-and-off-&-doseage-ups-and-downs with Gleevec due to side effects (not low or high blood counts, just everything else), I was off G for four weeks (to see if that helped my body deal with the side effects). My blood work then showed raised WBC and PCR, so I went back on G 400mg for one week while waiting for my Sprycel order to arrive. (G's side effects returned immediately, so I knew it was working!)
What is the reasoning for your husband to return to Gleevec, rather than switch to Sprycel or Tasigna, since he has already shown that he is too affected in his blood counts on G?
Be alert, but not overly concerned.
• Dx Oct. 22, 2008, WBC 459k, in ICU for 2 days + in hospital 1 week
• Leukapheresis for 1 week, to reduce WBC (wasn't given Hydroxyurea)
• Oct. 28, 2008: CML confirmed, start Gleevec 400mg
• Oct. 31, 2008: sent home when WBC reached 121k
• On/off, reduced dose Gleevec for 7 months
• April 2009: Started Sprycel 100mg
• Sept. 2009: PCRU 0.000
• Sept. 2011: after 2 years steady PCRU & taking Sprycel 100mg before bed, quit Sprycel (with permission)
• Currently: still steady PCRU, testing every 6 months 🤗
— Fatigue, hearing loss continue, alas, but I prefer to think it is all getting better!