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Zofran and Prolonged Q-T

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#1 Sneezy12


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Posted 15 September 2011 - 03:07 PM

The FDA has just issued a warning that Zofran may cause prolonged Q-T. I am unable to find any evidence of Q-T prolongation with Gleevec useage, but does anyone have any  scientific studies to the contrary? Thanks, Frank

#2 Trey


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Posted 15 September 2011 - 04:52 PM

All of the TKI drugs have at least some QT interval risk, but Gleevec has the least risk at 400mg and carries no QT warnings at all.  Tasigna is the only one with an FDA QT warning, but Sprycel has a QT warning from BMS, and is not much different than Tasigna in QT impact.  Tasigna just had some bad luck during the clinical trials.

Gleevec at 800mg has shown a more significant QT prolongation in one large study, even more significant than Sprycel:


(see page 2267)

Here is an overall discussion of heart related issues:


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