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#1 Shalom

Shalom

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Posted 13 September 2011 - 08:48 PM

http://www.uphs.upen...011/08/t-cells/

After I see this link I contacted Carl June he was so kind and he answerme back in a Sunday afternoon.

The LLS was a major supporter of our research.  We are working to adapt our CAR T cell approach to CML, so that one day, TKIs won't have to be taken for a lifetime. We hope to have trials for CML in the next year or 2.  Below is some general information on CAR T cell trials.  Thanks for your support of cancer research. Carl June

Thank you for your interest in our cancer research at the Translational Research Programs at the University of Pennsylvania (http://www.med.upenn...rc/CCVPF/?CCVPF). Please forgive this general message, because there has been an overwhelming number of inquiries. Some of the below information may be of use to you regarding CAR T cell trials for adult and pediatric leukemia, lymphoma, melanoma, myeloma, ovarian, brain, mesothelioma, sarcoma, breast cancer and prostate cancer; these are all early stage trials and are only available at the local city for the particular trial. I am not aware of CAR T cell trials for other types of cancer at this time.  We have added general information for other cancers such as pancreatic cancer.  We hope this is helpful.

The clinical trial you have heard or read about is for patients (both adults and children) with B cell cancers like CLL, non Hodgkin's lymphoma and ALL. For more details about the clinical trials for patients with B cell cancers, please see http://www.penncancer.org/cart-19/

For more details about the clinical trials for pediatric patients with B cell cancers, please see http://bit.ly/qb5Cik

This study is relevant for those with B cell CLL and Non-Hodgkin Lymphoma.

The clinical trial is currently on hold and not immediately enrolling additional patients.  As it reopens in the next 1-2 months, only about 15 patients will be able to be treated, until a larger trial opens in 2012.

            For those without Web access: contact Lester Lledo, Clinical Research Nurse,  215-746-6040

For children with leukemia in US seeking a second opinion, information is available at www.chop.edu/service/oncology/our-programs/pediatric-leukemia-and-lymphoma-program.html

Multiple myeloma

"Redirected Auto T Cells for Advanced Myeloma" clinicaltrials.gov NCT01352286

"Combination Immunotherapy and Autologous Stem Cell Transplantation for Myeloma" clinicaltrials.gov NCT01245673

Message was edited by: Abena



#2 LivingWellWithCML

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Posted 14 September 2011 - 06:09 PM

Wow, what a wonderful response from Carl June - thanks for sharing!  I have to think that a CAR T-Cell trial for CML in the next year or two is overly optimistic, but exciting to know that they are working on it now.

I wonder how they are funding the larger 2012 CLL trial, and how many patients they will be accepting?


Dan - Atlanta, GA

CML CP Diagnosed March 2011

Gleevec 400mg





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