I can understand and support Joel's decision to stop TKI therapy after 4+ years PCR undetectable. This is not for everyone. I think there needs to be 2 factors involved to think about this option. One is certainly a long term PCRU -- I would say the longer the better, and 2 years would be a minimum number. The other necessary component would be fast response to TKI therapy. Fast response shows high susceptibility of those higher level leukemic cells to TKI drugs. If this approach is going to work, the high level leukemic cells must be killed off. For it to work over the long term, all leukemic cells must be killed off. The big question remains to be answered: after several years of TKI therapy and PCRU, are the leukemic stem cells all gone? There is no answer to that. Research tells us that they are probably not all gone. But maybe they are. I have suggested (maybe wishful thinking?) that after many years of pounding by TKI drugs, the last leukemic cells would give up because of unknown mechanisms at work.
There is also another less drastic option to reduce TKI dosage which I have previously discussed. I have been PCRU for over 5 years. I reached PCRU in well under a year. I chose Gleevec dosage reduction down to 200mg per day, which I have been doing for 2 years now without loss of PCRU status. I also have almost no side effects.
http://community.lls.../message/112202
Joel is doing this in a smart way, under increased monitoring. Anyone who considers this should use the same approach.