I just got my 9 month bone marrow biopsy results and am happy to report my FISH showed only 1 in 399 cells are philly positive so less than 1%. I guess Tasigna ended up being the drug for me even though we don't always agree. I am feeling very happy and huge relief by this result. I have only been on Tasigna for 3 months the other 6 months were Gleevec.
9 month results are in....
Started by
jenz
, Sep 06 2011 03:22 PM
10 replies to this topic
#2
CallMeLucky
-
- Members
-
- 216 posts
Advanced Member
- LocationCT
Posted 06 September 2011 - 04:11 PM
Thats really awesome, congratulations.
Date - Lab - Scale - Drug - Dosage MG - PCR
2010/Jul - MSKCC - Non-IS - Gleevec - 400 - 1.2%
2010/Oct - MSKCC - Non-IS - Gleevec - 400 - 0.25%
2010/Dec - MSKCC - Non-IS - Gleevec - 400 - 0.367%
2011/Mar - MSKCC - Non-IS - Gleevec - 400 - 0.0081%
2011/Jun - MSKCC - Non-IS - Gleevec - 400 - 0%
2011/Sep - MSKCC - Non-IS - Gleevec - 400 - 0.00084%
2011/Dec - MSKCC - Non-IS - Gleevec - 400 - 0%
2012/Mar - MSKCC - Non-IS - Gleevec - 400 - 0.004%
2012/Jun - MSKCC - Non-IS - Gleevec - 400 - 0%
2012/Sep - MSKCC - Non-IS - Gleevec - 400 - 0%
2012/Dec - MSKCC - Non-IS - Sprycel - 100 - 0%
2013/Jan - Quest - IS - Sprycel - 50-60-70 - 0%
2013/Mar - Quest - IS - Sprycel - 60-70 - 0%
2013/Apr - CUMC - Non-IS - Sprycel - 50 - 0.036%
2013/May - CUMC - Non-IS - Sprycel - 50 - 0.046%
2013/Jun - Genoptix - IS - Sprycel - 50 - 0.0239%
2013/Jul - Genoptix - IS - Sprycel - 70 - 0.0192%
2013/Jul - Genoptix - IS - Sprycel - 70 - 0.0034%
2013/Oct - Genoptix - IS - Sprycel - 70 - 0.0054%
2014/Jan - Genoptix - IS - Sprycel - 70 - 0.0093%
2014/Mar - Genoptix - IS - Sprycel - 100 - 0.013%
2014/Apr - Genoptix - IS - Sprycel - 100 - 0.0048%
2014/Jul - Genoptix - IS - Sprycel - 100 - 0%
2014/Nov - Genoptix - IS - Sprycel - 100 - 0.047%
2014/Dec - Genoptix - IS - Sprycel - 100 - 0%
2015/Mar - Genoptix - IS - Sprycel - 100 - 0%
2015/Jun - Genoptix - IS - Sprycel - 100 - 0%
2015/Sep - Genoptix - IS - Sprycel - 100 - 0%
2015/Dec - Genoptix - IS - Sprycel - 100 - 0%
2016/Mar - Genoptix - IS - Sprycel - 100 - 0.0228%
2016/Jun - Genoptix - IS - Sprycel - 100 - 0%
2016/Sep - Genoptix - IS - Sprycel - 100 - 0%
2016/Dec - Genoptix - IS - Sprycel - 100 - 0%
2017/Mar - Genoptix - IS - Sprycel - 100 - 0%
2017/Jun - Genoptix - IS - Sprycel - 100 - 0%
2017/Sep - Genoptix - IS - Sprycel - 100 - 0%
2017/Dec - Genoptix - IS - Sprycel - 100 - 0%
#3
lala
-
- Members
-
- 0 posts
New Member
Posted 06 September 2011 - 05:51 PM
Hip hip hooray.......feel the happiness! -Lala
#4
LivingWellWithCML
-
- Members
-
- 60 posts
Advanced Member
- LocationAtlanta, GA
Posted 06 September 2011 - 06:19 PM
Wow, what a quick drop. That's awesome!!
Dan - Atlanta, GA
CML CP Diagnosed March 2011
Gleevec 400mg
#5
Pin
-
- Members
-
- 202 posts
Advanced Member
Posted 06 September 2011 - 06:26 PM
That's wonderful news jenz - It's amazing how these drugs work so differently in different people. Congratulations, and I hope your tests are all this good and better from now on! 
Diagnosed 9 June 2011, Glivec 400mg June 2011-July 2017, Tasigna 600mg July 2017-present (switched due to intolerable side effects, and desire for future cessation attempt).
Commenced monthly testing when MR4.0 lost during 2012.
2017: <0.01, <0.01, 0.005 (200mg Glivec, Adelaide) <0.01, 0.001 (new test sensitivity)
2016: <0.01, <0.01, PCRU, 0.002 (Adelaide)
2015: <0.01, <0.01, <0.01, 0.013
2014: PCRU, <0.01, <0.01, <0.01, <0.01
2013: 0.01, 0.014, 0.016, 0.026, 0.041, <0.01, <0.01
2012: <0.01, <0.01, 0.013, 0.032, 0.021
2011: 38.00, 12.00, 0.14
#6
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 06 September 2011 - 08:39 PM
Even that one reported leukemic cell was most likely a false positive. Since FISH is a color coded test, the colors can get mixed up when cells align just so. So that should be reported as zero, meaning CCyR.
#7
valiantchong
-
- Members
-
- 0 posts
New Member
Posted 06 September 2011 - 09:13 PM
Since 1 out of 399 may be a false positive may due to FiSH error rate. Should refer to the RT-PCR result for more detail.
#8
jenz
-
- Members
-
- 0 posts
New Member
Posted 07 September 2011 - 08:39 AM
I just received my molecular (BCR-ABL) results from my BMBX.. I think I am almost at a 3 log reduction, Trey?
PCR (11/08/11 - dx) 1.9
PCR (05/16/11 - last on Imatinib) 1.297
PCR (08/29/11 - first on Tasigna) 0.0094
#9
Tedsey
-
- Members
-
- 85 posts
Advanced Member
Posted 07 September 2011 - 03:30 PM
Yea Jenz! Happy to hear you are doing so well!
Teds
#10
Trey
-
- PS Beta Group
-
- 1,705 posts
Advanced Member
- LocationSan Antonio, Texas
Posted 07 September 2011 - 05:50 PM
It is likely a 3 log reduction by the lab standard. If International Scale, it certainly is -3 log. By your personal starting point (which was quite low by comparison to most people) it is over 2 log reduction. By any measure you are doing well.
#11
Happycat
-
- Members
-
- 5 posts
New Member
Posted 07 September 2011 - 07:33 PM
Wow, that Tasigna made a huge difference for you! Congrats and thanks for sharing the numbers!
Traci
1 user(s) are reading this topic
0 members, 1 guests, 0 anonymous users
