2 replies to this topic

[momruns]

CBC  -  WBC  2.7

            HGB   9.3

            HCT   28.9

            PLT   164

Bone Marrow  -  Metaphases counted :20     Analyzed: 20

                        There was no evidence of the Philadelphia chromosome seen previously or any other consistent chromosomal rearrangement to suggest an acquired clonal abnormality.

FISH results:  Positive for BCR-BCR-ABL1 Fusion, nuc ish (ABL1, BCR) x 3 (ABL1 con BCRx2) (13/100)

                     FISH showed evidence of a fusion of ABL1 and BCR.  Fusion signals for the BCR-ABL1 Dual Fusion probe were observed in 13% of cells examined in interphase.

BCR/ABL:      BCR-ABL/ABL ratio   0.559   (last time in June it was 0.299

                          Log reduction       0.869    (last time in June it was 1.141

Being a nurse I understand some but get confused easily.

He is keeping my on Gleevec 300mg/QD  with blood work in 2 weeks and then Q3wks, with f/u with him in 3 months.

I do realize it has only been since Feb 2011  So what do Trey and the rest of you guys think.

I take probiotics for the GI issues and it has helped alot.  I changed my work schedule to 4 10hr days so I get an extra day off (last week I had 50 hours in 4 days so I am glad I have a day off).

I am so grateful for this site, it has empowered me.

Loreta

[Trey]

Overall the news is good.  The BMB analyzed 20 dividing cells from the marrow and found none had the Philadelphia Chromosome (Ph+).  That is great, and would be called a Complete Cytogenetic Response (CCyR).  The FISH showed 13 of 100 cells were Ph+, so that does not show CCyR. So you could call your status "CCyR with an asterisk".

The PCR is higher but I would discount it due to the good BMB result.  There are so many factors that can cause a PCR to be higher without showing a lesser response.  PCRs are only useful when you look at the trend, not individual results.

HGB is low, so you are likely tired from that and other factors.  It should recover over time to a degree, but it is a stubborn issue and requires time.  The body seems to adjust over time to these issues.

[momruns]

Trey,

Thanks for your response.  I read the posts and log reduction seems to be the thing.  I am glad your said it is not a one time thing and I should be patient.  I am understanding the tests more and more with the help from you and your sites and everyone else on the site.  I see I am not alone.

Thanks again,

Loreta