Posted 22 August 2011 - 07:27 PM
If you only take zofran with Gleevec and not at other times of the day you could move it all to the morning. Nobody wants to change their routine but could be worth a try.
Another possibility is that the gleevec itself is going through an insomnia side effect phase, I'm pretty sure it is listed as a side effect. It could also be the combination of the two drugs but you are obviously combining them for a reason. How long does the zofran last for - would it be possible to take it an hour or two before gleevec and still squash the nausea but then be a little less wired at bed time.
One other thing is do you need to take it every day? My nausea is mild enough that I don't need it every day and can get away with taking the antiemetic as soon as I start feeling yuck and it still works.
Dx Dec 2010 @37
2x IVF egg collection
Glivec 600 & 800mg
PCRU March 2012
Unsuccessful pregnancy attempt - relapsed, 3 months interferon (intron A), bad side effects from interferon
Nilotinib 600mg Oct 2012
PCRU April 2013, 2 years MR4.5 mostly PCRU with a few blips
April 2015 stopped again for pregnancy attempt (donor egg), pregnant first transfer, 0.110 at 10wks, 2.1 at 14wks, 4.2 at 16wks, started interferon, slow dose increase to 25MIU per wk, at full dose PCR< 1 for remainder of pregnancy
Healthy baby girl Jan 2016, breastfed one month
Nilotinib 600mg Feb 2016
MMR May 2016
PCRU Feb 2017