(BTW, Michael -- your case is fascinating and continues to give us hope that natural methods can enhance our ability to beat this disease into submission. A few questions:
** What brand of fish oil supplement do you recommend?
** Were you taking 1g daily Curcumin + fish oil capsule when you were on Gleevec initially?
** To maximize absorption, any recommendations on what to eat/drink for breakfast when taking these two supplements? Is it a bad idea to take the TKI at the same time as these supplements?)
I use whatever fish oil my wife buys - it has a red cap, biggish bottle and the capsules are somewhat larger than vitamin pills. That's all I can say until I get home and actually look at it. I believe she buys it from Whole Foods or some such place. It's fish oil - if I break it open - it smells terrible - so I don't do that.
I never took Curcumin with Gleevec. I only started Curcumin during my first Sprycel break back in February. It was at that time that a friend of our family that wasn't suppose to know that I had CML - but my wife told her - told me to look into it - so I did. I was impressed enough that I started researching it and taking it during my long TKI break. It was during this time that Dr. Cortes was surprised that my counts were not climbing back faster (I was on zero therapy) - he expected my counts to bounce back over two weeks and then I would resume. He told me my counts were recovering at a rate that he sees from his transplant patients. My counts took months to come back. I believe it was the Curcumin suppressing the Leukemia. I wish I had tried Curcumin FIRST when first diagnosed to see what it would do to the WBC count as an experiment. I have a suspicion it would have leveled off the WBC growth (i.e. counts don't get worse) or even cause it to drop.
I actually started taking 3 grams, then 4 grams, six grams and then finally 8 grams of Curcumin around 3 months ago. I increased it every few days as per Dr. Aggarwal's suggestion. This was the 95% C3 Curcumin. It was a lot of capsules (500mg each). When I learned about BCM-95 - I switched to that formulation so I could take a lower dose that was as absorbant as 8 grams of normal Curcumin. Very important that you don't confuse doseage grams from one Curcumin to another. You need 8 grams worth of Curcumin per day.
I take Sprycel at night before I go to sleep with water. I take the Curcumin in the morning with a glass of Juice (lately - beet juice) and the fish oil. I don't take Curcumin and Sprycel at the same time - no reason not to - I just don't. I hate taking pills as it is.
Once I started taking 20mg. Sprycel - I had myelosuppression again, but not as bad, so I stayed on the medication. And that is when the big drops occurred over just two months.
I also take a folate supplement when I am not drinking beet juice and vitamin C when I can remember to take it (Trey's recommendation on the folate/C). I am somewhat anemic and need to support red blood cells as much as possible - although I have been feeling much more energetic since drinking beet juice the last week or so. My wife makes the beet juice from beets, plus apples and other stuff she throws in the juicer.
On Gleevec (even low dose at 300mg) I had the fatigue, muscle cramps and skin issues that you read about. On Sprycel - both 70mg initially and now my normal 20mg dose - I have none of that.
Diagnosed 11 May 2011 (100% FiSH, 155% PCR)
with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein
Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate
6-8 grams Curcumin C3 complex.
2015 PCR: < 0.01% (M.D. Anderson scale)
2016 PCR: < 0.01% (M.D. Anderson scale)
March 2017 PCR: 0.01% (M.D. Anderson scale)
June 2017 PCR: "undetected"
September 2017 PCR: "undetected"