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TKI Involvement with GERD / Acid Reflux

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#1 jenz


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Posted 11 August 2011 - 12:56 PM

I have been on Tasigna for about 10 weeks now and just recently have I started to have a burning sensation in my chest and a weird sore throat.  I have never really had this before and if so it was a very rare occasion.  So I am think that the TKI is causing it?  I do notice it is the worse after I take it morning or night. After reading various posts in here I know that these can be symptoms of GERD or Acid Reflux.  I also am aware that PPI drugs for heartburn or reflux can interact with TKI's.  I do not like this feeling and am worried to go try an over the counter medicine. 

I am curious has anyone else had a TKI cause this?  Anyone on Tasigna with this development? I am worried because it sure is uncomfortable nusance especially with the medicine being so troublesome with TKI's.


#2 Taylor



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Posted 11 August 2011 - 02:08 PM

Oh yeah, this was a big problem for me around the four-five month mark on Tasigna.  Tums helped, and I also tried having some manipulation done on my organs (sounds silly, I too was skeptical until it actually helped) and I haven't had too much of a problem after my body got used to it (or the GERD side-effect cycle finished).  But I still occassionally get that warmth.

It's a side effect but I think it has come about that taking Tums too soon with the medicine, or taking PPIs like Nexium, can inhibit the absorption of the medicine.

#3 lala


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Posted 11 August 2011 - 02:11 PM

Omgosh........was I sick last night with this same problem......I could not sleep........burning........I had a plain chicken quesadilla for dinner......I slept with my head on a million pillows.....horrible night's sleep....or rather, lack of one!  HELP!

#4 Jerry.s


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Posted 22 December 2014 - 03:58 PM

Hello Lala   did you find something to help you?  I am gleevec which is ok to take with Prilosec according to one study I read .  I take Gleevec and 4 Potassium pills and there causing so much acid reflux and maybe GERD.  I would like to know if you found something else to help. I am also taking a Proboitic but it doesn't seem to help.

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