Hi everyone,
I just received my 3-month FISH and PCR results today and have a few questions. Any feedback you all have would be greatly appreciated. I'm on Gleevec 400mg:
** PB FISH = 5% at 3 months (was 98% BM FISH at dx and 41.5% PB FISH at 6 weeks)
- Although not CCyR at 3 months, it's close. Despite what the guidelines say, is this fast enough to consider Gleevec the optimal TKI for now? I think it is, but I just need some reassurance based on others' experience with treatment and speed of response.
** PB RQ-PCR :: BCR-ABL1 to G6PDH Ratio = 1.53E-02
- What's the number that I should put into my PCR spreadsheet? 1.53? Is this good/bad/indifferent at 3 months? BM PCR at dx was 2.5E-01 (25.0).
- The report defines baseline as the following: "Baseline represents the average BCR-ABL1/G6PDH ratio for a patient with CML, chronic phase, who has not received therapy." Have others seen their PCR "baseline" defined in this fashion, and where does this average come from? Is this a form of international standardization? Confusion reigns.
- Given the definition of baseline above, here are the result details in the report. Is this how others are measuring the march toward MMR and (hopefully) CMR?
- 19.13% of baseline
- -0.72 log change from baseline
- 19.13% of baseline
Thanks for your help in understanding this stuff, folks -
Dan