Hi, I'm Becky 28, from Indianapolis, IN and I was recently diagnosed with CML on June 20th. Last week when I had my 2nd follow up with my hematologist, he told me that I have the presence of P190 which qualifies me as high risk due to studies showing that patients with this variance have decreased chances of responding to TKI. Does anyone have this variation? What was your course of treatment? I'm currently taking 600 mg of Gleevec and seeing my hematologist every two weeks, however, we have been communicating through email more frequently due to his concern for it being high risk.
My doctor recommended a second opinion since he has not worked with any patients with these characteristics. I have done some research and will be going to Mayo Clinic in Rochester within the next month or so to get a full diagnostic. The only information my doctor was able to give me was this article (link below) which does not have a very positive outcome. Anything anyone can tell me about this would be a huge help.