I am not new here, but I haven't been here for a couple of years. My history with CML is: I was diagnosed three years ago; I've been on 400mg mg Gleevec since then, everything seems goods with bloodwork; I experience limited side effects, mostly fatigue, nausea, muscle cramps, brain fog. Mostly because to my job situation, I've been experiencing depression for several months now and my primary just prescribed Prozac. Has anyone here on Gleevec tried this combination? The information on the web that I can find only says that the Prozac may increase concentration of the Gleevec in the blood.