So, it's been smooth sailing so far on Gleevec 400mg ... almost three months in. However, I received a Jun 21 metabolic panel from the onc (in the mail and with no notes, ouch!), and two key liver numbers were up ... note that they were perfectly normal and steady until this point:
- AST (SGOT) = 137 IU/L (above normal)
- ALT (SGPT) = 46 IU/L (stil normal, but markedly higher than my last check)
I don't think these values on their own are much reason for concern at this point, but I wanted to see if others on Gleevec had to ensure some early elevation in liver numbers ... and perhaps a settling-in or decline as the body and liver got used to processing the toxicity of the medication. I've almost eliminated every other variable - I weaned off blood pressure medication over the past couple of weeks (at the advice of my doctor - he felt that I could give it a shot), and I was taking a couple of other medications during late May and early-mid June and I'm almost done with everything. I'm expecting to only be taking Gleevec by next week. My red wine intake was definitely up during the July 4th holiday (LOL), but I'm prepared to stop consumption if needed - although I don't think it's the culprit because I was drinking a couple of small glasses of red wine per night throughout the early course of treatment with great liver numbers.
I wonder if the short-term medications I was taking in late May/early-mid June could've caused a temporary rise? I suppose it's all speculation until I get my next panel...
Just curious if others endured an up-down or up-steady trend like this on Gleevec and survived to tell the tale without having to make a TKI switch. I've been so happy with the absence of Gleevec side effects and am hoping/praying that this isn't a trend for the worse.