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Is Feverfew extract (parthenolide) a cure for leukemia ?


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#1 cousineg

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Posted 01 July 2011 - 08:57 PM

Some links about feverfew at http://www.cmleukemia.com/feverfew-extract-parthenolide.html



#2 Susan61

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Posted 02 July 2011 - 06:10 PM

The use of Feverfew has been a topic many times through the years as being a cure by killing the root of the leukemia cells. The last thing I read on it was that they could not make a safe enough compound to be taken orally.  They are working on it, but I would advise anyone not to just start popping feverfew thinking they are going to cure their Leukemia.  You have to be careful what you take along with your TKI's.

Maybe Trey has some better information regarding this subject.  I wish it were that easy.  If it were, we would all be on it already.

I just keep praying for that cure to come.  We are so blessed with the invention of all these TKI's to give people a long life.

Susan



#3 valiantchong

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Posted 02 July 2011 - 11:18 PM

This herbal medication is also used for migraine and athritis. It is also know as Little white Chrysenthanum in chinese herbal medication, normaly taken as flower tea.

I was wondering, the properties of this herb if taken with cucumin or forkolin along with TKI will it cause problem ?

Hopefully in next few years feverfew extract or parthenolide will show good results as TKI...



#4 Susan61

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Posted 03 July 2011 - 01:17 PM

Hi:  Yes it is the Chrysantemum or Batchelor Button flower, but nobody should mix these herbal or vitamin things together.  Always check with your doctor.  I was told no Green Tea, nothing but a mult-vitamin which I was told to take Centrum Silver one a day for people over 50.  I am also low on Vitamin D, therefore, I am on Vitamin D daily.

      I feel if I have done this well without fooling around with all this other stuff that could throw off my accomplishments with my TKI for over 10 years, then why start now.

     I have to see fool proof evidence with approval by the FDA that all the research has been done to qualify all this as safe and EFFECTIVE.

    I will tell anyone to just do what we have been doing for now.  Not saying we may not be able todo more within the next few years to fight our CML.

    This is just my opinion.  My doctor has not been wrong so far.

Susan



#5 JoshLee

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Posted 03 July 2011 - 05:21 PM

Hi,

     I am going to jump in here. I just returned from lunch with a friend who was diagnosed with ALL when she was 15 and then relapsed when she was in her early 20's. She is actually on a clinical trial in Rochester, NY that has patients who have relapsed with AML. She actually relapsed with a combination of both.AML and ALL She is taking Parthenolide and has been 0 PCR for some time now. Of course, she is taking this in combination with Sprycel, HOWEVER, she is soon going to go off of Sprycel in hopes that the Parthenolide (as part of the trial) will keep it under control and actually, they aren't really having a problem with its toxicity, it's more that it is not easily absorbed into the body. She has been living with this relapse under control for about 5 years or so. There is HOPE in parthenolide, just don't hold your breath I guess. I also don't think everyone should start taking this because we really don't know what will happen, but it's worth asking your onc. about it I think. The doctors don't really know why my friend is still so healthy, but she continues to do well and just maybe there will be something really exciting to come out of all of this. We owe a lot of gratitude to people on clinical trails paving the way for our futures. Happy 4th of July, everyone!! -Josh



#6 valiantchong

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Posted 03 July 2011 - 10:41 PM

Hi Josh,

Wondering what is the dossage of your friend taking the parthenolide daily ? Or she is taking just like a mixture of hot water with the flower together to make tea like drink....

Is the medication taken under her doc presription or knowledge ?, 

I am consdiering trying since it is also good for headache and it is a common daily drink for chinese.



#7 Susan61

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Posted 03 July 2011 - 10:57 PM

HI:  Thanks for sharing that information.  It gave me more hope for new things to come.  I guess with me being PCRU since 2003, I just do not want to mess things up in any way.  I do think that things need to be discussed with a CML Specialist before taking anything.  I always tell people to be sure their doctor is specializing in CML, because not all Oncologists I am finding really know everything there is to know.

If anyone is going to try the Feverfew, please keep us informed on here.  Like I said its been up for discussion for quite a few years now.

Susan



#8 CallMeLucky

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Posted 05 July 2011 - 06:11 AM

I hate to be the cynic here, but Feverfew is really cheap.  I don't see anyone breaking down doors to run trials on this stuff.

Hopefully someone will prove me wrong.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#9 Trey

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Posted 05 July 2011 - 11:31 AM

Cousin,

Do you take Feverfew?  Are you going to stop TKI treatment?



#10 cousineg

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Posted 06 July 2011 - 09:55 AM

Hi Trey,

                        I saw my CML doctor last week.  He told me that I can stop Gleevec in December 2011.  I want to try feverfew before I will stop Gleevec. However, my CML doctor didn't give me information about feverfew. In October 24, we will see Dr. Mahon from France in Montreal. I believe there will be a lot of CMLers in this meeting.

                         Since 2007, we have no news about feverfew. In fact, a CMLer took fevefew and is now in remission for 18 months without TKI treatment.  Perhaps, I will meet him in the meeting (October 24) .

Thank you for all the work you have done,

Gilles



#11 valiantchong

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Posted 06 July 2011 - 10:59 AM

What is the dosage of the feverfew ? in capsule ?



#12 JoshLee

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Posted 06 July 2011 - 11:42 AM

Hi Valiant Chong,

      I think my friend is on 150mg of parthenolide. However, I think there's feverfew and then the amount of parthenolide in feverfew. I think most extracts only contain small amounts of parthenolide. I asked my onc. about it yesterday and he told me that he didn't know a lot about it and discouraged it for me because things are going alright for me 5 months into treatment... Which I know is like the equivalent to like the first 1/2 mile in life long marathon. He told me it might be wise not to mess with my response at this point. I think you might want to talk to a CML specialist. I think there are people that take this already, but getting an expert opinion might help you make a more informed decision. Good luck!! -Josh



#13 scuba

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Posted 06 July 2011 - 12:13 PM

There seems to be no more papers post 2005 on Feverfew?  If so potent, why is there no more research on it?


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#14 JoshLee

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Posted 06 July 2011 - 12:36 PM

All I know is that I have a friend on Parthenolide that is involved in a trial at the University of Rochester, NY that is on a combination of Pathenolide and Sprycel as part of a clinical trial. This means there is still research being done on Parthenolide. How much research? I have no clue. 



#15 CallMeLucky

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Posted 06 July 2011 - 01:21 PM

Could you ask your friend for any details on the trial and post back?

II searched Clinicaltrials.gov and could only find two trials for parthenolide, they were both for allergies and both are closed.  I also found reference to a phase I trial from 2004, but nothing else.

http://www.ncbi.nlm....pubmed/15122077


Phase I dose escalation trial of feverfew with standardized doses of parthenolide

in patients with cancer



Source

Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA.

Abstract
PURPOSE:

Feverfew  is a botanical product that contains parthenolide. Parthenolide has in  vitro and in vivo anti-tumor and anti-angiogenic activity. Feverfew has  been used extensively without any formal pharmacokinetic analysis. A  Phase I trial was conducted to evaluate the pharmacokinetics and  toxicity of parthenolide given as a component of "feverfew."

PATIENTS AND METHODS:

Feverfew  (Tanacet trade mark) was administered as a daily oral tablet in a  28-day cycle. A starting dose of 1 mg per day was explored with  subsequent dose escalations to 2, 3, and 4 mg. Assessment of plasma  pharmacokinetics was performed on patients accrued to the trial. Solid  phase extraction and mass spectroscopy were used to evaluate  parthenolide plasma concentrations. The limit of detection for  parthenolide in plasma was 0.5 ng/ml. Patients were evaluated for  response after every two cycles.

RESULTS:

Feverfew given  on this schedule had no significant toxicity, and the maximum tolerated  dose was not reached. When parthenolide was administered at doses up to 4  mg as a daily oral capsule in the feverfew preparation, there was not  detectable concentration in the plasma. Because of this, parthenolide  pharmacokinetics were not able to be completed.

CONCLUSION:

Feverfew,  with up to 4 mg of parthenolide, given daily as an oral tablet is well  tolerated without dose-limiting toxicity, but does not provide  detectable plasma concentrations. Purification of parthenolide for  administration of higher doses will be needed.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#16 valiantchong

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Posted 06 July 2011 - 10:02 PM

If the parthenolide is not detected in plasma, then the efficacy of the meidication is not there... no wonder the is no further experiment on this.. or could it be if this works then no drugs company could make profit sice this herb is cheap....any inputs ?



#17 mengkemao

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Posted 09 July 2011 - 08:01 AM

Hi I'm the new comer.

I'm doing some reseach based on google recently. I found some interesting things want to share with all of you. comments are welcome.

Because of the poor solubility, the parthenolide is bad bioavailability as a cure for leukemia. Guzman et al found that a serum concentration of about 2.5 ?mol/L was needed to start killing the leukemic cells, and that about 5 ?mol/L was optimum, during the mice testing. How to acchieve this level,  is the main problem that there is no drug coming out till now?

The exciting point:

http://ash.confex.co...Paper14001.html This article is for Multiple Myeloma, but I think it's also related with leukemia.

Dimethylaminoparthenolide (DMAPT) is a water-soluble analog of parthenolide. The improved bioavailability of DMAPT makes its appealing for clinical development.

But I can not find more information, where to get DMAPT? the dosage?  This paper was published in 2008, seems no news comes for long time.



#18 valiantchong

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Posted 09 July 2011 - 08:42 AM

I guess the reason it may work but no drug company could profit... so no one is interested making it a workable drug... Probably some company now trying to make a synthetic similar molecule structure on this drug... so could patent them and sell them with a huge profit.....any input ... ?? 



#19 scuba

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Posted 09 July 2011 - 09:54 AM

http://bloodjournal....0/13/4427.short

So why has this not gone anywhere?


Diagnosed 11 May 2011 (100% FiSH, 155% PCR)

with b2a2 BCR-ABL fusion transcript coding for the 210kDa BCR-ABL protein

 

Sprycel: 20 mg per day - taken at lights out with Quercetin and/or Magnesium Taurate

6-8 grams Curcumin C3 complex.

 

2015 PCR: < 0.01% (M.D. Anderson scale)

2016 PCR: < 0.01% (M.D. Anderson scale) 

March        2017 PCR:     0.01% (M.D. Anderson scale)

June          2017 PCR:     "undetected"

September 2017 PCR:     "undetected"


#20 Trey

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Posted 09 July 2011 - 04:54 PM

Besides the poor bioavailability issue (which can be overcome to a degree), the reason Feverfew and its extract Parthenolide have not made more progress in fighting leukemia is that while it inhibits AML leukemic cells in one way, Parthenolide works against itself in another way.  So in essence, Parthenolide cancels itself out to a rather significant degree.  So research is trying to find ways to decrease this self-cancellation mechanism.

http://bloodjournal....6/5983.abstract






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