Just a quick question from the UK. I received a call from my consulatant today who said he had been advised that I should be moved onto a 2nd Generation TKI. As I haven't been intolerant of Gleevec, maybe a slight resistance and have no mutations they have given me a choice of which one to take.
I have been on Glivec for 19 months. My last PCR was 0.293 (2.3 log reduction) but has been around the same area for the last 10 months hence the change to try to get a deeper response.
I am erring on the Dasatanib side just due to the routine of taking it and not having to have an empty stomach as with Nilotinib.
Does anyone have any advice on which one would be most suitable/tolerable and comments for and against either?
Also if you have to change do you have to come off Glivec for a period before switching or is it a straight switch over?
Many thanks in advance