I read in a couple of posts that someone had e-mailed Dr. Drucker about Tasigna dosing and he said that dosing on a 16/8 hour intervial was fine since Tasigna's half-life is 16 hours. I am considering doing this. I currently take 2x150mg 2x/day. I find that right now at approx. 10:15AM and 10:15PM works well for overall scheduling, but if I go to bed immediately after that (which I do during the week), I find my first hour or two of sleep is frequently interrupted by insomnia, which also sometimes causes me to wake up with a slightly racing heart and being irritable/anxious--although this aspect may be tied to some sort of anxiety as well. If I go to bed a couple hours later after this dose, like on the weekends, I tend to stay asleep after going to bed.
I also feel like if I know I will be having some anxiety in the night (another problem I'm battling), particularly by feeling irritable or anxious or having an elevated heart rate before bed, I am more able to try something like chamomile tea. We're told to stay away from the tea due to an effect on serum levels, but if the dosage has been going through me five or so hours before, it may not be as much as a problem.
In any case, I'm curious to how this 16/8 dosage works with blood serum levels. We have the Tasigna fast from food because of serum levels and the QT concern--of which, despite all the encouragement, I'm still wary about. Would taking the dosages 8 hours apart instead of 12 hours apart not be doing basically the same thing?
Thanks for any thoughts.