Surprise surprise ...
I have been somewhat myelo-suppressed for 5 months while at the same time taking zero drugs.
After one week of being on Sprycel at 20mg. (very low dose) look at my numbers. I have had a 30% increase in Neutrophils:
ANC = 1.31 (last week prior to Dasatinib re-start = 0.92) First time above 1.0 in 5 months.
WBC = 3.0 (last week = 2.6)
(other WBC's = normal)
RBC = 3.54 (last week = 3.67)
HGB = 12.0 (last week = 12.9)
HCT = 36.7 (last week = 37.7)
MCV = 105 (last week = 103)
Platelets = normal at 215 (last week = 206)
I am also taking 8 grams of Curcumin per day. From what I have read, Curcumin enhances Sprycel in the body. I am willing to take the risk combining the two so don't try this at home. Follow my results and who knows, maybe they will start a formal trial involving the two compounds for CML. I am taking the Curcumin as a combination attack on CML. Sprycel goes after the disease on the inside of the cell (which means it has to be absorbed into the cells) and Curcumin goes after the disease on the cell membrane. Between the two, I am hoping for a very fast Leukemic load reduction (PH+ chromosome). Right now I have little PH+ in my circulating blood (FISH = zero). But I am loaded in the bone marrow (100% PH+). I can't fathom why this is ...
I am at a loss why my Neutrophils have jumped AFTER I re-started sprycel. When I first started Sprycel at 70 mg. (still a lower than normal dose), my Neutrophils after one week plummeted over 50%. So I expected a drop when I re-started again. My other WBC's are normal and Platelets (the canary early warning sign) are rock solid normal).
What a fascinating disease.
(p.s. Curcumin has done wonders for my intestinal tract. Memo to Trey: try it - your sharts will go away).