1 reply to this topic

[Jarhead]

So,

Been PCRU for about a year...currently taking 70mg Sprycell...back in feb it came back at .02 (originally over 100%)...Doctors were assured if was a false positive...beginning of this month it was .12....had a BMB at this time as well and it was clean and good to go...they uped my Sprycell to 100 mg...

I guess my question is, will upping the dosage potentially bring it back down?

[Trey]

Since your diagnosis is Ph+ Acute Lymphocytic Leukemia instead of CML, the TKI drugs can have a tougher time.  This is due to the additional instability of the ALL.  The PCRs may have been accurate given the way ALL can respond.  For ALL, the response can be good for a while, but there is a much higher failure rate than for CML.  The increased dosage may work, but only time will tell.  You should have frequent PCRs to monitor the situation (suggest every 6 weeks or even monthly).