Okay, not that I'm not happy to hear it, but everything about my diagnosis was so weird, it just seems to get stranger and stranger.
My WBC was 42K last week at diagnosis. The rest of the bloodwork was fine.
However, my blood smear had so many promyelocytes, they thought I must have APML. Plus, I was bruising very badly (why I got the CBC to begin with), so their initial dx (from multiple docs) was APML.
Much testing later, and a few incorrect results (didn't find the APML 15/17 translocation, then thought they saw an APML-variant 11/17), they finally found 199 out of 200 cells by FISH were positive for bcr-abl. The lab director thinks the probe for 11/17 just isn't that good, so believed it to be an aberrant result. They followed up with a karyotype just to be sure, and saw only the CML 9/22 translocation.
They think the bruising was due to high amounts of ibuprofen I was taking and possibly the cortisone shots I had for my neck pain. (I bruise every time I have cortisone, so it's either cortisone alone or cortisone with ibuprofen doing it to me.)
Still, it bothers me that my blood smear had so many promyelocytes. Keep thinking it's a sign of more aggressive disease or some strange mutation that will ultimately make me resistant to Gleevec. Do we ever stop wondering about this???
Anyway, after 1 wk on Gleevec, my WBC was 8.1K, back to normal, with no promyelocytes in my blood smear.
Did anyone else have high promyelocytes (and mainly just those) in their blood? How weird am I?