I've stopped progressing, stuck at about 2 log reduction for past 4 months, about 16 months into treatment. Changing to 300 mg Tasigna twice a day next week. I questioned my doctor why Tasigna rather than Spyrcel, reasoning didn't seem that strong. My thought is that it would be good to know based on genetic testing if one is better than the other. Anyone else been in this position of being stalled out? If so how was the selection of the second generation drug done?