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No longer PCRU

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#1 WoofWoof


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Posted 30 March 2011 - 01:02 PM

You know it's going to be a bad day when your Onc. calls you first thing in the morning. Latest BCR/ABL results showed I went from PCRU to 1.4% in the last three months. I've been on Tasigna for about 15 months after first being on Gleevec and having pretty bad side effects. Within six months I went to a four log reduction but looks like those days are over

for now. Anyone else have this experience & what could it mean? My Dr. said to just sit tight (like  that's possible) and we will retest in three weeks. Any advise would be greatly appreciated.

I have cancer but it doesn't have me

#2 Trey


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Posted 30 March 2011 - 01:21 PM

You were diagnosed about 3 years ago -- what has been your detailed PCR history?

But I would not be inclined to sit tight or sit loose or sit any particular way.  The PCR could be wrong, but I would request an immediate retest of the PCR and also a Kinase Mutation Test.

#3 simone4


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Posted 30 March 2011 - 03:05 PM

Woof, I had a similar experience last Oct.  I was not PCRU but my PCR

showed a 2-log increase.  My onc had me come in immediately and

performed a BMB, checking for all that could be wrong.  The result was

a 3-log decrease. Thus the lab made a mistake. I could not get in

his office fast enough for my BMB. I wanted a resolution fast.

Why does your onc think sitting on this will change?

Take care and good luck.


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