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Article-Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML

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#1 SunNsand



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Posted 27 March 2011 - 02:57 PM


Any thoughts on this or is this nothing new?


#2 Trey


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Posted 27 March 2011 - 05:19 PM

I have not seen this discussed as a significant issue.  The numbers in the sample are small, but the outcome requires some amount of attention, so more studies are required to understand this potential issue.  Meanwhile, it would be worth reading about PAOD to know the symptoms in case anyone notes them, so they can alert their doctor.  Essentially, PAOD is atherosclerosis of peripheral arteries (aka, hardening of the arteries not near the heart).  Also it should be noted that Tasigna can raise glucose levels in the blood, so this could possibly be related.  Exercise is a key in prevention of PAOD.  (I know -- too tired to get off the couch).


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