Just received my latest PCR results and have some questions. I was diagnosed May 6, 2010, started 400mg Gleevec May 15, 2010. At diagnosis FISH was 100%, no PCR done (my Dr has indicated that even though PCR wasn't done at diagnosis he would assume it was 100%, not sure this assumption can be made?). At 3 months FISH was 11.5%, PCR was 2.17%. At 6 months FISH was 0%, PCR was .01%. My 9 month PCR is at .006%. So my question is, if what the Dr said is true and I started at 100% on PCR, what is my log reduction? And if it's not true that we can assume I started at 100% PCR, what is my log reduction?
I have tolerated Gleevec quite well with fatigue and running on the lower end of normal for my WBC, RBC, HGB, PLT & ANC. My question is for those that have switched from Gleevec to Sprycel, have you experience a noticeable change in your fatigue level. Is there anyone who feels like they are back to there normal activity level?
I understand and have painfully realized that I will have a new normal, but I was hoping my energy level would be a little better. I have been doing a lot of the things that are talked about on this board; exercise, vitamins and eating healthy. I went to a "Cancer Related Fatigue" workshop a couple of months ago and the trainer said the thing that would help me the most with fighting fatigue was strength training...UGH, I despise weights, I'm a cardio person! Well, I have given it a try when I have the energy after 8 hours at work and I have to say I have noticed a difference. But when you start the day tired, that second wind that used to come around doesn't anymore, you just get more tired as the day progresses and working out after work is not very appealing.
I have talked to my Dr at length about the fatigue and he/we have decided to give it a couple more months to see if it improves. If in 3 months there is no change then we may look at Sprycel. I am hesitant to change drugs as I have done very well on Gleevec with my response and very few side effects. However, what if I have the same experience on Sprycel and the fatigue is noticeable different, then it would be worth it to switch. It's a very hard decision, which is why I'd like to hear from everyone that has made a drug change and how you responded to it. Also, is anyone that is on Gleevec not feeling the fatigue? If so, what's your secret...please share! As a side note, I have tried to convince my Dr that maybe lowering my dose to 300mg might help with my blood counts and the fatigue, he gave me the big NO. He said he would switch me to Sprycel first before he would lower the Gleevec dose.
I would appreciate your thoughts.