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Could CML use Fetal Stem Cell Treatment, such as Emcell to improve to cure CML ?


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#1 valiantchong

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Posted 06 March 2011 - 10:58 AM

Anyone has any knowledge on Stem Cell treatment on CML treatment instead of the drastic HSCT with hash chemotherapy ?

Could CML treatment to use Fetal stem cell treatment to improve treatment or improve immunological response ?



#2 Trey

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Posted 06 March 2011 - 12:43 PM

If you are talking about cord blood transplants, they are usually not as effective as a well-matched allogeneic transplant.  Both require the same general preparation procedures.

This would help you understand some basic information about the differences:

http://en.wikipedia....transplantation

But if you are talking about treatments using injection of early stage fetal stem cells, it cannot cure leukemia since that is not a transplant process.  But it can apparently help with difficult cases of anemia by supplying additional stem cells that will not be rejected by the host, since early stage fetal stem cells do not have HLA antigens.

http://www.emcell.com/en/treatment.htm



#3 valiantchong

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Posted 07 March 2011 - 06:47 AM

Looks like the answer is no.... wondering  if Embryo stem cell research will help ?



#4 PhilB

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Posted 07 March 2011 - 08:07 AM

Hi VC,

Embryonic stem cell treatments have great potential to treat diseases where the patient has too little of something eg if neurons or other tissues are dieing off.  Cancer patients have the exact opposite problem ie we have far too much of something because our cells are breeding uncontrollably (unless we can stop them with a drug such as a TKI).  The only way to cure CML is to take something away (the Ph+ stem cells) so adding something won't help.  The only exceptions are the cases Trey mentions where they might be able to give us a population of healthy cells if our own aren't surviving the treatment used to kill the cancerous ones.

Phil



#5 valiantchong

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Posted 07 March 2011 - 08:49 AM

HI Phil,

What I am thinking is, Stem cell could create new immune or antibody system that could defend against the IL1RAP or CD34+ antigen on CML cell. Since base on the law of the fittest cell survive, it may help to drive or wash out the CML stem cell. As I know even the CML stem cell has lifetime may be they may divide for about 60 times and will die out...Any posibility ???






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