My last visit to the doctor he told me that he though I was becoming resistant to the Gleevec. I have been on Gleevec for four years. I am taking 600mgs.
My PCR bloodwork is going up slightly. I wrote about this in another post.
Below is part of my other post about having an ABL Kinase Mutation Test done:
I believe that the doctor told me that I reached a CCYR. On my PCR bloodwork I have never reached a 0.000 and I seem to fluctuate
even though it does seem like I am always very close to 0.000....So I have never reacher MMR.
I don't understand all of this very well but my BCR-ABL t (9;22)fusion tests were:
7/20/07 0.144
9/14/07 0.144
12/27/07 0.098
3/28/08 0.028
5/28/08 0.018
10/23/08 0.015
1/07/09 0.041
2/23/09 0.035
3/20/09 0.014
4/23/09 0.014
7/27/09 0.027
11/4/09 0.009
2/5/10 0.011
5/3/10 0.004
11/17/11 0.007
2/7/11 0.011
So he told me today that my numbers are going up and that because I have never gotten to 0 which I am assuming means 0.000 (CMR)
that he thinks I am resistant to the Gleevec and that I need to have a blood test ABL Kinase Mutation to see if I would tolerate the other
medicines. I hope this information might help you.
Now, I am breaking out with red spots on my arms and upper trunk area. There might be other areas as I have not searched myself fully but they are not
the same size. Some are larger than others. They are red in color and some feel slightly raised up. I looked at the petechia picture with the purpleish colored looking dots on the foot and that does NOT look like what I have. They do not itch or bother me but in the last few days it seems like more are
developing.I was just wondering if these might be a symptom of being RESISTANT to the Gleevec? I did put a call into the doctor and he is calling me back.