There is new evidence that acid reflux medications interfere with TKI drugs at two important points. These medications are called proton pump inhibitors (PPI -- including Prilosec, Nexium, etc). The first interference by these PPI medications is that they interfere with TKI drugs being absorbed from the gastrointestinal tract. But there is also a second interference, whereby these acid reflux medications also interfere at the cell level and reduce TKI drug intake into the cell, so less TKI drug enters into the leukemic cells where the BCR-ABL is located. So these acid reflux drugs can be "double bad" for those of us taking TKI drugs.
The interference is worse for Gleevec than the others, followed by Sprycel. Oddly, Tasigna cell uptake of TKI drug seems to be enhanced (made better) by the acid reflux drugs, probably because Tasigna is taken into the cells in a slightly different way. But Tasigna intake from the GI tract would likely offset cell uptake advantages. So it would be best to stay away from all acid reflux drugs while taking TKI drugs. If that is not possible, it would probably be better to take Tasigna while taking acid reflux drugs.