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Any news on Vaccine theraphy than this one ?


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#1 valiantchong

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Posted 31 January 2011 - 12:15 PM

Complete molecular response in CML after p210 BCR-ABL1-derived peptide vaccination

Monica Bocchia, Marzia Defina, Lara Aprile, Micaela Ippoliti, Rosaria Crupi, Michela Rondoni, Alessandro Gozzetti & Francesco Lauria

Abstract

Background. A 63-year-old woman with chronic myeloid leukemia (CML) received treatment with interferon (IFN)-? for 6 years. After achieving a complete cytogenetic response that was repetitively documented, IFN-? treatment was stopped. Despite maintenance of a complete cytogenetic response, a progressive rise of the BCR-ABL1 transcript was detected and loss of major molecular response occurred about 2 years after stopping IFN-? therapy. Disease remained at molecular level.

Investigations. Peripheral blood quantitative real-time PCR every 3 months and periodical bone marrow aspirate were performed to monitor disease.

Diagnosis. Chronic-phase, Philadelphia-positive CML that was still detectable after complete cytogenic response 2 years after cessation of IFN-? therapy.

Management. The patient was treated with a target immune approach receiving a therapeutic vaccine that consisted of an immunogenic 25-mer b2a2 breakpoint-derived peptide (CMLb2a2-25) with binding properties for several HLA-DR molecules. After nine boosts of vaccine the patient developed an adequate b2a2-25 peptide-specific CD4+ T-cell response and BCR-ABL1 transcript started to decline in peripheral blood. No hematological or extrahematological effects were documented during therapy. At the last evaluation, 39 months since vaccinations commenced, the patient is in complete molecular response with an undetectable level of BCR-ABL1 transcript both in peripheral blood and in bone marrow and she continues to receive boosts of vaccine every 3 months as the only treatment.



#2 GerryL

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Posted 01 February 2011 - 02:42 AM

Hello,

There is some information on a trial being conducted in Southampton

Southampton scientists begin patient trials of new leukemia cancer vaccine

A new cancer treatment which strengthens a patient's immune system and enables them to fight the disease more effectively is being trialled on patients for the first time in the UK.

The treatment will use a new DNA vaccine, developed by scientists from the University of Southampton, which will treat a selected group of volunteers who have either chronic or acute myeloid leukaemia - two forms of bone marrow and blood cancer.

The remainder of the article is available at    http://www.physorg.c...s-leukemia.html



#3 Trey

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Posted 01 February 2011 - 11:04 AM

This would be a good opportunity for folks in the UK to volunteer for the leukemia vaccine clinical trial discussed in the link Gerry provided.  More info below:

http://pharmalive.co...rticleid=757981



#4 valiantchong

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Posted 01 February 2011 - 11:54 AM

Any FDA approved vaccine rather than GVAX in the market ? Which has proven to work in the market as efficient as TKIs ?



#5 Trey

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Posted 01 February 2011 - 04:11 PM

No.  The vaccine issue has a long way to go as far as I can tell.  That is why the clinical trials are important.



#6 PhilB

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Posted 01 February 2011 - 04:39 PM

I'll be speaking to my Haemetologist in 12 days (PCR results time again - Eek!) and will definitely ask about taking part as it's only 25 miles down the road from me.  The gizmo they're using to electrocute bits of you before they inject the vaccine sounds a bit weird and wonderful!

Phil



#7 GerryL

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Posted 01 February 2011 - 06:30 PM

I'm not sure that you're meant to enjoy it Phil - but you never know - if it is an easier method for getting an injection, I'm all for it.



#8 CallMeLucky

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Posted 01 February 2011 - 07:13 PM

I'd play it cool, don't seem to interested or excited at the being electrocuted part.


Date  -  Lab  -  Scale  -  Drug  -  Dosage MG  - PCR
2010/Jul -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 1.2%
2010/Oct -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.25%
2010/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.367%
2011/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.0081%
2011/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2011/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.00084%
2011/Dec -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Mar -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0.004%
2012/Jun -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Sep -  MSKCC  -  Non-IS  -  Gleevec  - 400 - 0%
2012/Dec -  MSKCC  -  Non-IS  -  Sprycel  - 100 - 0%
2013/Jan -  Quest  -  IS  -  Sprycel  -  50-60-70  - 0%
2013/Mar -  Quest  -  IS  -  Sprycel  -  60-70  - 0%
2013/Apr -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.036%
2013/May -  CUMC  -  Non-IS  -  Sprycel  - 50 - 0.046%
2013/Jun -  Genoptix  -  IS  -  Sprycel  - 50 - 0.0239%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0192%
2013/Jul -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0034%
2013/Oct -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0054%
2014/Jan -  Genoptix  -  IS  -  Sprycel  - 70 - 0.0093%
2014/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.013%
2014/Apr -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0048%
2014/Jul -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2014/Nov -  Genoptix  -  IS  -  Sprycel  - 100 - 0.047%
2014/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2015/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0.0228%
2016/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2016/Dec -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Mar -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Jun -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Sep -  Genoptix  -  IS  -  Sprycel  - 100 - 0%
2017/Dec - Genoptix  -  IS  -  Sprycel  -  100 - 0%
 

 


#9 Guest_billronm_*

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Posted 02 February 2011 - 12:09 AM

Dear Phil

                That test sounds a bit creepy to me.If you do it I want every detail word for word. After they electrocate you, If you hear the words was it good for you? Run like hell.                                            Sincerely Billie






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