I was diagnosed with CML on 11/8/09 and had a WBC of 321K. After CML was confirmed by a BMB, I was put on HydroxyUrea and Allopurinol for 2 days. On 11/18, I started Gleevec 400 mg and have been on Gleevec ever since (discontinued Gleevec for about 1 week in Dec. 2009 since platelets went very low). At this time I tolerate Gleevec quite well (apart from the weight gain).
At the 6 month mark, I achieved a 1.5 log reduction and at the 12 month mark I reached a 2.1 log reduction with q-PCR test. The q-PCR test has continually shown a decrease since my Oncologist started measuring it from 2/2010 (~3 months after I was diagnosed).
At this time, my Onc says that it would be a good idea to shift to Tasigna becuase I have not reached MMR (a 3-log reduction). According to the Onc., while I continue to respond well to Gleevec and the 'bad-cells' have been decreasing, at this time I should have been at the 3-log mark. Does this mean that I am resistant to Gleevec? My only concern is related to the QT prolongation associated with Tasigna. Since I have a family history of Heart trouble, I am a little concerned if I should shift to Tasigna or should I continue with Gleevec for some more time?
My research has not shown anything conclusive about the need to reach 3-log reduction in 12 months (Possibly not looking at the right places). Is there some research that shows that shifting to Tasigna (or Sprycell) is warranted at the 12-month mark if MMR is not achieved?
Trey and others—Please help.